LSUHSC CARC Overall The Louisiana State University Health Sciences Center New Orleans (LSUHSC-NO) Comprehensive Alcohol- HIV/AIDS Research Center (CARC) is a multi-institutional, multidisciplinary team of scientists from LSUHSC and the Tulane National Primate Research Center (TNPRC) and School of Public Health and Tropical Medicine (TSPHTM) with a research focus on the interaction of alcohol use disorder (AUD), human immunodeficiency virus (HIV), and antiretroviral therapy (ART). The translational focus is the impact of at-risk alcohol consumption on risk for comorbidities in a longitudinal cohort of in-care virally-suppressed persons living with HIV (PLWH). We have demonstrated the relevance of the simian immunodeficiency virus (SIV) nonhuman primate (NHP) model to the clinical setting, revealed the deleterious impact of alcohol despite viremic control in in-care PLWH, and identified environmental (neighborhood) and behavioral (diet) factors that affect disease course and severity. The proposed studies evolve, expand, and refine our research strategy to a mechanistic bidirectional (NHP? PLWH?NHP) translational investigation of the impact of AUD, HIV, and ART on comorbid conditions in an underserved cohort of PLWH. The scientific premise of the proposed studies is the observation that intestinal mucosa is an early site of alcohol-induced immunopathogenic changes in the alcohol-consuming, HIV/SIV- infected host that culminates in loss of mucosal barrier function and gut leak that promotes chronic immune activation, inflammation, and senescence, which we hypothesize increases risk for comorbidities in PLWH. An Administrative Core provides oversight, supports data management and analysis, and funds pilot projects to promote novel research investigations. Four Research Components (RCs) study in-care underserved PLWH and a sex- and age-matched HIV- control group, complemented by mechanistic studies in SIV+ and SIV- NHPs. RC1 investigates the impact of community and interpersonal stress on behavioral and chronic comorbidities among PLWH and the unique role that alcohol consumption plays in the pathways. RC2 and RC3 elucidate pathophysiological mechanisms of two comorbidities: metabolic dysregulation and neurological deficits. RC4 investigates the immunological mechanisms driving the balance between immune activation and activation- induced cell death that contribute to cell senescence and tissue injury with alcohol exposure. An Experimental and Analytical Resource Core provides support for all proposed studies. An Information Dissemination Core promotes training and accelerates the translation and dissemination of research findings to the scientific, health care, and lay communities. The CARC will continue to leverage and synergize with existing institutional resources. Access to a unique HIV+ population in a southeast urban region, the established expertise of CARC investigators in biomedical and behavioral research, state-of-the-art research facilities, outstanding scientific environment, and strong institutional support will ensure that the proposed CARC projects will continue to advance our understanding of the comorbid consequences of AUD, HIV/SIV, and ART in PLWH.

Public Health Relevance

LSUHSC CARC Overall The Louisiana State University Health Sciences Center New Orleans Comprehensive Alcohol-HIV/AIDS Research Center (LSUHSC-NO CARC) is a multi-institutional, multidisciplinary team of scientists focused on understanding the interaction of alcohol use disorders, human immunodeficiency virus, and antiretroviral therapy. CARC activities encompass clinical and mechanistic bidirectional translational studies, training, mentoring, and information dissemination.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA009803-28
Application #
10075852
Study Section
Special Emphasis Panel (ZAA1)
Program Officer
Lin, Li
Project Start
1996-12-01
Project End
2024-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
28
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Louisiana State Univ Hsc New Orleans
Department
Physiology
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
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Glick, Jennifer L; Theall, Katherine; Andrinopoulos, Katherine et al. (2018) For data's sake: dilemmas in the measurement of gender minorities. Cult Health Sex :1-16
Theall, Katherine P; Felker-Kantor, Erica; Wallace, Maeve et al. (2018) Considering high alcohol and violence neighborhood context using daily diaries and GPS: A pilot study among people living with HIV. Drug Alcohol Depend 187:236-241
Simon, Liz; Siggins, Robert; Winsauer, Peter et al. (2018) Simian Immunodeficiency Virus Infection Increases Blood Ethanol Concentration Duration After Both Acute and Chronic Administration. AIDS Res Hum Retroviruses 34:178-184

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