Abstract

The Indiana University Arthritis Center (IUMPAC) consists of four components: Biomedical Research, Education, Community/Health Services Research (C/HSR) components, and Administration Unit. Major biomedical research interests include cartilage biology, pathogenesis of osteoarthritis (OA), amyloidosis, immune tolerance, synovial biology, and effects of lymphokines on muscle. New Developmental/Feasibility studies relate to the above areas and to: exercise effects in fibromyalgia, hydraulics of subchondral bone, oncogenes in autoimmunity, factors modifying the efficacy of intra-articular steroids, the natural history of osteonecrosis, as revealed by nuclear magnetic imaging, and development of an arthrosonographic instrument to measure thickness and other properties of joint cartilage. The Education Component is concerned with training of Fellows, house staff, and medical and allied health professions (AHP) students. It includes outreach programs to train community physicians and AHPs in diagnosis and treatment of arthritis. Pediatric rheumatology receives particular attention. New projects deal with effects of professional education and interdisciplinary networking on care of elderly patients with arthritis; use of standardized patient observers in education of physicians and dentists about temporomandibular joint syndromes; effects on outcomes of increased participation of the arthritis patient in outpatient visits; effectiveness of group education programs; and computer-assisted instruction to modify inappropriate use of allopurinol. The C/HSR Component works with community agencies in programs to improve the well-being of clients with arthritis. New C/HSR projects deal with the effects of enhanced social support on outcomes in patients with OA; determinants and consequences of """"""""dropping out"""""""" of treatment by a rheumatologist; effects of juvenile arthritis on cognitive development and patient/family adaptation; effects of the physician's specialty on charges and outcomes in patients with OA; effects of home care for patients with rheumatoid arthritis; and the relationship of type of surgery to costs of care and health outcomes in elderly patients with hip fracture.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
5P60AR020582-12
Application #
3108163
Study Section
(ADDK)
Project Start
1977-09-15
Project End
1991-11-30
Budget Start
1988-12-01
Budget End
1989-11-30
Support Year
12
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Mazzuca, Steven A; Brandt, Kenneth D; Katz, Barry P et al. (2007) Risk factors for early radiographic changes of tibiofemoral osteoarthritis. Ann Rheum Dis 66:394-9
Merle-Vincent, F; Vignon, E; Brandt, K et al. (2007) Superiority of the Lyon schuss view over the standing anteroposterior view for detecting joint space narrowing, especially in the lateral tibiofemoral compartment, in early knee osteoarthritis. Ann Rheum Dis 66:747-53
Otterness, Ivan G; Brandt, Kenneth D; Le Graverand, Marie-Pierre Hellio et al. (2007) Urinary TIINE concentrations in a randomized controlled trial of doxycycline in knee osteoarthritis: implications of the lack of association between TIINE levels and joint space narrowing. Arthritis Rheum 56:3644-9
Mazzuca, S A; Brandt, K D; Eyre, D R et al. (2006) Urinary levels of type II collagen C-telopeptide crosslink are unrelated to joint space narrowing in patients with knee osteoarthritis. Ann Rheum Dis 65:1055-9
Brandt, Kenneth D; Mazzuca, Steven A (2006) Experience with a placebo-controlled randomized clinical trial of a disease-modifying drug for osteoarthritis: the doxycycline trial. Rheum Dis Clin North Am 32:217-34, xi-xii
Mazzuca, S A; Brandt, K D; Katz, B P et al. (2006) Comparison of quantitative and semiquantitative indicators of joint space narrowing in subjects with knee osteoarthritis. Ann Rheum Dis 65:64-8
Mazzuca, Steven A; Poole, A Robin; Brandt, Kenneth D et al. (2006) Associations between joint space narrowing and molecular markers of collagen and proteoglycan turnover in patients with knee osteoarthritis. J Rheumatol 33:1147-51
Mikesky, Alan E; Mazzuca, Steven A; Brandt, Kenneth D et al. (2006) Effects of strength training on the incidence and progression of knee osteoarthritis. Arthritis Rheum 55:690-9
Hellio Le Graverand, M-P; Brandt, K D; Mazzuca, S A et al. (2006) Association between concentrations of urinary type II collagen neoepitope (uTIINE) and joint space narrowing in patients with knee osteoarthritis. Osteoarthritis Cartilage 14:1189-95
Brandt, Kenneth D; Mazzuca, Steven A; Katz, Barry P et al. (2005) Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum 52:2015-25

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