This proposal is in response to RFA AR-00-0012, NIAMS Multi- disciplinary Clinical Research Center and is a watershed for the phasing out of the Multipurpose Arthritis Center program and a transition to a Clinical Research Center. Building on a rigorous active preclinical research program and investigator initiated clinical sciences program built over 20 years, we submit 3 proposals whose goals is to improve patient outcomes, a Biometry and Methodology Care to provide consultation and practical support to all projects and Administrative care to enhance interactions and responsiveness to new research opportunities. The research goals of project 1 are to understand the relationships between surgeon-and hospital-volume of total knee arthroplasty and to elucidate the mechanisms by which volume affects outcomes. To know these mechanisms will allow us to improve the effectiveness of this major procedure. It uses powerful statistical tools of claim analysis. Project 2 dissects the effects of functional literacy on outcome and tests a novel intervention to overcome the health disadvantages for subjects with systemic rheumatic diseases who have literacy problems. It breaks new ground in arthritis and musculoskeletal diseases and new methods have been developed to permit its study. It breaks new ground in arthritis and musculoskeletal diseases and new methods have been developed to permit its study. Project 3 attempts to improve SLE patients outcomes and reduce the incidence of accelerated atherosclerosis. That patients with SLE have an exceedingly high risk of accelerated atherosclerosis. That patients with SLE have an exceedingly high risk of accelerated atherosclerosis has been known for over 20 years. It's prevention is unknown the project is a proof of concept study using a cardiac risk profile as a surrogate endpoint.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
1P60AR047782-01
Application #
6345815
Study Section
Special Emphasis Panel (ZAR1-TLB-B (J1))
Program Officer
Freeman, Julia B
Project Start
2001-06-15
Project End
2006-03-31
Budget Start
2001-06-15
Budget End
2002-03-31
Support Year
1
Fiscal Year
2001
Total Cost
$1,339,171
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Kreps, David J; Halperin, Florencia; Desai, Sonali P et al. (2018) Association of weight loss with improved disease activity in patients with rheumatoid arthritis: A retrospective analysis using electronic medical record data. Int J Clin Rheumtol 13:1-10
Solomon, Daniel H; Lu, Bing; Yu, Zhi et al. (2018) Benefits and Sustainability of a Learning Collaborative for Implementation of Treat-to-Target in Rheumatoid Arthritis: Results of a Cluster-Randomized Controlled Phase II Clinical Trial. Arthritis Care Res (Hoboken) 70:1551-1556
Prado, Maria G; Iversen, Maura D; Yu, Zhi et al. (2018) Effectiveness of a Web-Based Personalized Rheumatoid Arthritis Risk Tool With or Without a Health Educator for Knowledge of Rheumatoid Arthritis Risk Factors. Arthritis Care Res (Hoboken) 70:1421-1430
Lee, Moa P; Lii, Joyce; Jin, Yinzhu et al. (2018) Patterns of Systemic Treatment for Psoriatic Arthritis in the US: 2004-2015. Arthritis Care Res (Hoboken) 70:791-796
Barbhaiya, Medha; Tedeschi, Sara K; Lu, Bing et al. (2018) Cigarette smoking and the risk of systemic lupus erythematosus, overall and by anti-double stranded DNA antibody subtype, in the Nurses' Health Study cohorts. Ann Rheum Dis 77:196-202
Sparks, Jeffrey A; Iversen, Maura D; Yu, Zhi et al. (2018) Disclosure of Personalized Rheumatoid Arthritis Risk Using Genetics, Biomarkers, and Lifestyle Factors to Motivate Health Behavior Improvements: A Randomized Controlled Trial. Arthritis Care Res (Hoboken) 70:823-833
Yu, Zhi; Lu, Bing; Agosti, Jenifer et al. (2018) Implementation of Treat-to-Target for Rheumatoid Arthritis in the US: Analysis of Baseline Data From a Randomized Controlled Trial. Arthritis Care Res (Hoboken) 70:801-806
Bido, Jennifer; Ghazinouri, Roya; Collins, Jamie E et al. (2018) A Conceptual Model for the Evaluation of Surgical Missions. J Bone Joint Surg Am 100:e35
Sparks, Jeffrey A; Chang, Shun-Chiao; Nguyen, Uyen-Sa D T et al. (2018) Smoking Behavior Changes in the Early Rheumatoid Arthritis Period and Risk of Mortality During Thirty-Six Years of Prospective Followup. Arthritis Care Res (Hoboken) 70:19-29
Sparks, Jeffrey A; Chang, Shun-Chiao; Nguyen, Uyen-Sa et al. (2018) Weight Change During the Early Rheumatoid Arthritis Period and Risk of Subsequent Mortality in Women With Rheumatoid Arthritis and Matched Comparators. Arthritis Rheumatol 70:18-29

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