The overall objective of the Methodology Core (MC) is to promote high quality clinical researcl{ in musculoskeletal disease by providing innovative statistical and research methodologies, specialized data bases, computational resources, and educational programs for. the MCRC.
The specific aims of the MC are 1) to facilitate the implementation and completion of all MCRC projects by providing expertise in biostatistics, research design, outcomes research, data management and computing, 2) to provide access to specialized data basesand computing resources, 3) to provide a mechanism for research review and data and safety monitoring for MCRC projects, and 4) to provide an educational forum that fosters excellence in clinical research by conducting monthly research-in progress seminars, workshops on methods for clinical research, and directed research courses and mentoring pre and post-doctoral trainees within the MCRC. The MC builds on methodological and educational expertise in other programs and centers at Dartmouth, including the SPORT Statistics and Data Management Core, the NCCC Biostatistics Shared Resource, the Clinical Research Section of the Department of Medicine, and the Center for the Evaluative Clinical Sciences. Two highly trained staff members with extensive experience on core MCRC projects are named to key MC positions. Existing computational resources and network facilities are made available through arrangements with other centers and Dartmouth's Kiewit Computer Services. Specialized data bases essential to the success of individual MCRC projects are assembled and maintained by the MC. MC resources are made available to members of the Research Base with chargebacks as appropriate. Oversight of the MC is provided by the MCRC Director. Progress is tracked through monthly reports detailing resource usage.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Comprehensive Center (P60)
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Special Emphasis Panel (ZAR1)
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Dartmouth College
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Abdu, William A; Sacks, Olivia A; Tosteson, Anna N A et al. (2018) Long-Term Results of Surgery Compared With Nonoperative Treatment for Lumbar Degenerative Spondylolisthesis in the Spine Patient Outcomes Research Trial (SPORT). Spine (Phila Pa 1976) 43:1619-1630
Klare, Christian M; Fortney, Thomas A; Kahng, Peter W et al. (2018) Prognostic Factors for Success After Irrigation and Debridement With Modular Component Exchange for Infected Total Knee Arthroplasty. J Arthroplasty 33:2240-2245
Skolasky, Richard L; Scherer, Emily A; Wegener, Stephen T et al. (2018) Does reduction in sciatica symptoms precede improvement in disability and physical health among those treated surgically for intervertebral disc herniation? Analysis of temporal patterns in data from the Spine Patient Outcomes Research Trial. Spine J 18:1318-1324
Passias, Peter G; Poorman, Gregory; Lurie, Jon et al. (2018) Patient Profiling Can Identify Spondylolisthesis Patients at Risk for Conversion from Nonoperative to Operative Treatment. JB JS Open Access 3:e0051
Prohaska, Matthew G; Keeney, Benjamin J; Beg, Haaris A et al. (2017) Preoperative body mass index and physical function are associated with length of stay and facility discharge after total knee arthroplasty. Knee 24:634-640
Suri, Pradeep; Pearson, Adam M; Zhao, Wenyan et al. (2017) Pain Recurrence After Discectomy for Symptomatic Lumbar Disc Herniation. Spine (Phila Pa 1976) 42:755-763
Mata-Fink, Ana; Philipson, Daniel J; Keeney, Benjamin J et al. (2017) Patient-Reported Outcomes After Revision of Metal-on-Metal Total Bearings in Total Hip Arthroplasty. J Arthroplasty 32:1241-1244
Gerling, Michael C; Leven, Dante; Passias, Peter G et al. (2017) Risk Factors for Reoperation in Patients Treated Surgically for Degenerative Spondylolisthesis: A Subanalysis of the 8-year Data From the SPORT Trial. Spine (Phila Pa 1976) 42:1559-1569
Austin, Daniel C; Keeney, Benjamin J; Dempsey, Brendan E et al. (2017) Are Barbed Sutures Associated With 90-day Reoperation Rates After Primary TKA? Clin Orthop Relat Res 475:2655-2665
Keeney, Benjamin J; Koenig, Karl M; Paddock, Nicholas G et al. (2017) Do Aggregate Socioeconomic Status Factors Predict Outcomes for Total Knee Arthroplasty in a Rural Population? J Arthroplasty 32:3583-3590

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