The clinical unit at Presbyterian Hospital provides excellent personalized care to nearly 300 patients with sickle cell diseases, both in Pediatrics and Medicine. The out-patient facilities are housed in two new and modern outpatient facilities: in Medicine in the Atchley Pavilion, in Pediatrics in the Harkness Pavilion. These facilities, specifically dedicated to hematology patients are, """"""""single class"""""""" units. The patients feel special, removed from the crowded clinics of the Hospital and access these facilities frequently and freely. The clinical units have a core of professionals who have through the years generated close relationships with the patients. These include, besides physicians, nurse practitioners and social workers exclusively dedicated to sickle cell patients both in the out-patient and in-patient care. The unit provides education to the community, in cooperation with our very active self-help group (Sickle cell Organization for Self Help--SCOSH), offers counseling, encourages voluntary screening and facilitates prenatal diagnosis. Although the clinical unit """"""""per se"""""""" is not designed to perform research projects, it provides patients and/or blood samples to the other components of the center. Clinical observations are collected and analyzed. For instance, the analysis of how cultural differences affect children's hospitalization rates will be continued, taking advantage of the presence in our clinical of two different ethnic groups: Afro- Americans and Latin-American.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Comprehensive Center (P60)
Project #
5P60HL028381-18
Application #
6325919
Study Section
Project Start
2000-04-01
Project End
2001-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
18
Fiscal Year
2000
Total Cost
$135,505
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Prohovnik, Isak; Hurlet-Jensen, Anne; Adams, Robert et al. (2009) Hemodynamic etiology of elevated flow velocity and stroke in sickle-cell disease. J Cereb Blood Flow Metab 29:803-10
Manwani, Deepa; Galdass, Mariann; Bieker, James J (2007) Altered regulation of beta-like globin genes by a redesigned erythroid transcription factor. Exp Hematol 35:39-47
Weinberg, Rona S; Ji, Xinjun; Sutton, Millicent et al. (2005) Butyrate increases the efficiency of translation of gamma-globin mRNA. Blood 105:1807-9
Rubin, Camelia Iancu; French, Deborah L; Atweh, George F (2003) Stathmin expression and megakaryocyte differentiation: a potential role in polyploidy. Exp Hematol 31:389-97
Day, Nancy S; Tadin, Marija; Christiano, Angela M et al. (2002) Rapid prenatal diagnosis of sickle cell diseases using oligonucleotide ligation assay coupled with laser-induced capillary fluorescence detection. Prenat Diagn 22:686-91
Turhan, Aslihan; Weiss, Linnea A; Mohandas, Narla et al. (2002) Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm. Proc Natl Acad Sci U S A 99:3047-51
Iancu, C; Mistry, S J; Arkin, S et al. (2001) Effects of stathmin inhibition on the mitotic spindle. J Cell Sci 114:909-16
Frenette, P S; Weiss, L (2000) Sulfated glycans induce rapid hematopoietic progenitor cell mobilization: evidence for selectin-dependent and independent mechanisms. Blood 96:2460-8
Pearson, M J; Lipowsky, H H (2000) Influence of erythrocyte aggregation on leukocyte margination in postcapillary venules of rat mesentery. Am J Physiol Heart Circ Physiol 279:H1460-71
O'Neill, D W; Schoetz, S S; Lopez, R A et al. (2000) An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells. Mol Cell Biol 20:7572-82

Showing the most recent 10 out of 114 publications