Type 2 diabetes mellitus (diabetes) is a growing public health problem. Chronic infections have been suggested as a potential risk factor for diabetes and there is a known association between periodontal infections and diabetes. Although it is generally believed that periodontal infections are a consequence of existing diabetes, there is growing support for the hypothesis that periodontal infections might contribute tq diabetogenesis, although research on this topic is limited. The evidence supporting the role of periodontal infections as a risk factor for a number of other systemic diseases (i.e., cardiovascular disease and pregnancy outcomes) continues to grow and further supports the rationale for. the current research proposal. Furthermore, recent reports implicate inflammation as a strong risk factor for incident diabetes. Since the inflammatory response is a central aspect of periodontal pathology, it is of interest to explore whether or not inflammation might mediate the association between periodontal disease and diabetes, or simply be an underlying contributor to both disease processes. The current proposal aims to test the hypothesis that periodontal infection is an etiologic factor in the development of diabetes. Baseline exposure to known periodontal pathogens will be assessed to see if elevated infectious exposure is associated with accelerated progression of fasting glucose and insulin levels. This will be achieved using a longitudinal cohort design among n=300 participants in a population of men and women aged 25 - 55 years at baseline enrollment. The proposed design will carefully control for potential confounders such as baseline levels of fasting glucose, insulin, lipids, obesity, diet, age, smoking, ethnicity and gender.

Public Health Relevance

The proposed research can advance the-scientific knowledge regarding the well-known association between periodontal infection and diabetes through its provision of a powerful study design appropriate for addressing temporarily (i.e., do periodontal infections precede the onset of diabetes pathology), hi addition, data on the independent contribution of infections to the underlying pathology of diabetes can be addressed for the first time using a population based, chronic infection model

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Research Transition Award (R00)
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Special Emphasis Panel (NSS)
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Atkinson, Jane C
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Columbia University (N.Y.)
Public Health & Prev Medicine
Schools of Public Health
New York
United States
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Ong, Paulina; Lovasi, Gina S; Madsen, Ann et al. (2017) Evaluating the Effectiveness of New York City Health Policy Initiatives in Reducing Cardiovascular Disease Mortality, 1990-2011. Am J Epidemiol 186:555-563
Demmer, Ryan T; Breskin, Alexander; Rosenbaum, Michael et al. (2017) The subgingival microbiome, systemic inflammation and insulin resistance: The Oral Infections, Glucose Intolerance and Insulin Resistance Study. J Clin Periodontol 44:255-265
Suglia, Shakira F; Demmer, Ryan T; Wahi, Richa et al. (2016) Depressive Symptoms During Adolescence and Young Adulthood and the Development of Type 2 Diabetes Mellitus. Am J Epidemiol 183:269-76
Goh, Charlene E; Kopp, Jacob; Papapanou, Panos N et al. (2016) Association Between Serum Antibodies to Periodontal Bacteria and Rheumatoid Factor in the Third National Health and Nutrition Examination Survey. Arthritis Rheumatol 68:2384-93
Colombo, Paolo C; Doran, Amanda C; Onat, Duygu et al. (2015) Venous congestion, endothelial and neurohormonal activation in acute decompensated heart failure: cause or effect? Curr Heart Fail Rep 12:215-22
Kotsakis, Georgios A; Thai, Ashley; Ioannou, Andreas L et al. (2015) Association between low-dose aspirin and periodontal disease: results from the continuous national health and nutrition examination survey (NHANES) 2011-2012. J Clin Periodontol 42:333-41
Boillot, Adrien; Demmer, Ryan T; Mallat, Ziad et al. (2015) Periodontal microbiota and phospholipases: the Oral Infections and Vascular Disease Epidemiology Study (INVEST). Atherosclerosis 242:418-23
Demmer, Ryan T; Gelb, Sara; Suglia, Shakira F et al. (2015) Sex differences in the association between depression, anxiety, and type 2 diabetes mellitus. Psychosom Med 77:467-77
Demmer, R T; Jacobs Jr, D R; Singh, R et al. (2015) Periodontal Bacteria and Prediabetes Prevalence in ORIGINS: The Oral Infections, Glucose Intolerance, and Insulin Resistance Study. J Dent Res 94:201S-11S
Feuer, Alexis J; Demmer, Ryan T; Thai, Ashley et al. (2015) Use of selective serotonin reuptake inhibitors and bone mass in adolescents: An NHANES study. Bone 78:28-33

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