Abstract

The molecular signals that guitde cell migration during development and regeneration of the cornea are largely unl

Public Health Relevance

The proposed research aims to provide an insight Into the role of guidance molecules during neural crest migration into the eye during development. Understanding the role of guidance molecules during these processes may provide clues on how the migration pattern of cells Is disrupted In congenital eye disorders and wound healing.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Transition Award (R00)
Project #
5R00EY018050-04
Application #
7780368
Study Section
Special Emphasis Panel (NSS)
Program Officer
Shen, Grace L
Project Start
2007-09-01
Project End
2011-11-30
Budget Start
2009-12-01
Budget End
2010-11-30
Support Year
4
Fiscal Year
2010
Total Cost
$246,510
Indirect Cost

  Institution

Name
Rice University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
050299031
City
Houston
State
TX
Country
United States
Zip Code
77005

  Publications

Spurlin 3rd, James; Lwigale, Peter (2013) A technique to increase accessibility to late-stage chick embryos for in ovo manipulations. Dev Dyn 242:148-54
Kwiatkowski, Sam; Munjaal, Ravi P; Lee, Teresa et al. (2013) Expression of pro- and anti-angiogenic factors during the formation of the periocular vasculature and development of the avian cornea. Dev Dyn 242:738-51
Griswold, Shannon L; Lwigale, Peter Y (2012) Analysis of neural crest migration and differentiation by cross-species transplantation. J Vis Exp :
Schwend, Tyler; Lwigale, Peter Y; Conrad, Gary W (2012) Nerve repulsion by the lens and cornea during cornea innervation is dependent on Robo-Slit signaling and diminishes with neuron age. Dev Biol 363:115-27
McKenna, Chelsey C; Munjaal, Ravi P; Lwigale, Peter Y (2012) Distinct roles for neuropilin1 and neuropilin2 during mouse corneal innervation. PLoS One 7:e37175
McKenna, Chelsey C; Lwigale, Peter Y (2011) Innervation of the mouse cornea during development. Invest Ophthalmol Vis Sci 52:30-5
Lwigale, Peter Y; Bronner-Fraser, Marianne (2009) Semaphorin3A/neuropilin-1 signaling acts as a molecular switch regulating neural crest migration during cornea development. Dev Biol 336:257-65