Abstract

- Research in the lymphatic circulation is exciting and rich in challenges as its importance in immune cell trafficl

Public Health Relevance

- Despite the vast importance of the lymphatic system for lipid transport, almost nothing is known about how it is actively regulated or about the biology of lipid transport and metabolism by lymphatics. A few clinical correlations and experimental obsen/ations have linked the two, but this proposed research will establish foundational basic studies on how lymphatics actively affect lipid metabolism and will develop critical in vivo and in vitro tools for studying lipid trafficking and processing by the lymphatic endothelium as well as targeting lymphatics with lipophilic drugs . Thus, this work will contribute to the eventual design of rational therapies to treat lymphedema, obesity, and other related disorders.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Transition Award (R00)
Project #
4R00HL091133-02
Application #
7929080
Study Section
Special Emphasis Panel (NSS)
Program Officer
Goldman, Stephen
Project Start
2009-09-10
Project End
2012-07-31
Budget Start
2009-09-10
Budget End
2010-07-31
Support Year
2
Fiscal Year
2009
Total Cost
$233,550
Indirect Cost

  Institution

Name
Georgia Institute of Technology
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
097394084
City
Atlanta
State
GA
Country
United States
Zip Code
30332

  Publications

Kornuta, Jeffrey A; Nepiyushchikh, Zhanna; Gasheva, Olga Y et al. (2015) Effects of dynamic shear and transmural pressure on wall shear stress sensitivity in collecting lymphatic vessels. Am J Physiol Regul Integr Comp Physiol 309:R1122-34
Nelson, Tyler S; Akin, Ryan E; Weiler, Michael J et al. (2014) Minimally invasive method for determining the effective lymphatic pumping pressure in rats using near-infrared imaging. Am J Physiol Regul Integr Comp Physiol 306:R281-90
Kornuta, Jeffrey A; Dixon, J Brandon (2014) Ex vivo lymphatic perfusion system for independently controlling pressure gradient and transmural pressure in isolated vessels. Ann Biomed Eng 42:1691-704
Reed, Alana L; Rowson, Sydney A; Dixon, J Brandon (2013) Demonstration of ATP-dependent, transcellular transport of lipid across the lymphatic endothelium using an in vitro model of the lacteal. Pharm Res 30:3271-80
Kornuta, Jeffrey A; Nipper, Matthew E; Dixon, J Brandon (2013) Low-cost microcontroller platform for studying lymphatic biomechanics in vitro. J Biomech 46:183-6
Weiler, Michael; Dixon, J Brandon (2013) Differential transport function of lymphatic vessels in the rat tail model and the long-term effects of Indocyanine Green as assessed with near-infrared imaging. Front Physiol 4:215
Kassis, Timothy; Kohan, Alison B; Weiler, Michael J et al. (2012) Dual-channel in-situ optical imaging system for quantifying lipid uptake and lymphatic pump function. J Biomed Opt 17:086005
Weiler, Michael; Kassis, Timothy; Dixon, J Brandon (2012) Sensitivity analysis of near-infrared functional lymphatic imaging. J Biomed Opt 17:066019
Nipper, Matthew E; Dixon, J Brandon (2011) Engineering the Lymphatic System. Cardiovasc Eng Technol 2:296-308
Dixon, J Brandon (2010) Lymphatic lipid transport: sewer or subway? Trends Endocrinol Metab 21:480-7

Showing the most recent 10 out of 12 publications