Electronic Health Records (EHRs) can improve the quality of healthcare delivery in the United States, by providing automated best-practice reminders to clinicians and patients. However such functionality is currently limited to narrow areas of clinical practice, as existing decision support systems can process only structured data, due to lack of a suitable framework and concerns about accuracy and portability. Preliminary work by the PI has shown that rule-based approach can be used to develop broad-domain reminder systems that can utilize free-text in addition to the structured data. The PI has developed prototype systems for cervical and colorectal cancer prevention. These systems consist of rule-based composite models of national guidelines, and rule-based Natural Language Processing (NLP) parsers. The NLP parsers extract the patient variables required for applying the guidelines. However further research is needed to extend the systems and to ensure their accuracy for clinical deployment. In the mentored phase, the PI will collaborate with clinicians to extend and iteratively optimize and validate the systems, and will make them available in open-source so that they can be adapted for deployment at other institutions (aim 1 - K99). In the independent phase, the PI will research methods to facilitate rapid development, deployment and cross- institutional portability of similar systems. Specifically, the PI will develp a hybrid design for the parsers and investigate domain adaptation and active learning methods, for reducing the manual effort for development and adaptation of the NLP parsers (aim 2 - R00). To enable other researchers to reuse the developed methodologies and software resources, a toolkit will be developed that will support the construction and deployment of similar systems (aim 3 - R00). The toolkit will consist of user-friendly tools and templates to replicate the processes engineered in the case studies, and will build on the SHARPn data normalization tooling and other open-source tools. The independent phase will be in collaboration with Intermountain Healthcare. The PI's career goal is to become a scientific leader in clinical informatics with a focus on optimizing clinical decision making. The PI has strong background in clinical medicine and medical informatics, and will receive mentoring from Drs. Hongfang Liu, Christopher Chute, Robert Greenes and Rajeev Chaudhry, who have complimentary areas of expertise. The mentored (K99) phase will be for 2 years at Mayo Clinic Rochester, wherein the PI will undertake courses on decision support and will get mentored training in NLP and health information standards. This will prepare the PI for independent research in R00 phase on portability and tooling. Completion of the proposed work will enable the PI to seek further funding for piloting clinical deployment of the developed systems, measuring their clinical impact, and for scaling the approach to other clinical domains and institutions. The career grant will enable the PI to establish himself as an independent investigator and to make significant contributions towards advancing clinical decision support for improving care delivery.

Public Health Relevance

The potential of Electronic Health Records (EHRs) to improve care delivery by providing best-practice reminders is unrealized, because reminder systems currently operate in narrow areas of clinical practice, as they can process only structured data. The proposed framework will enable construction of reminder systems that can encompass broader areas of practice, due to their capability to utilize free-text as well as structured EHR data. This pioneering research directly impacts public health by improving the quality of care through enhanced reminder functionality in the EHRs.

National Institute of Health (NIH)
National Library of Medicine (NLM)
Research Transition Award (R00)
Project #
Application #
Study Section
Biomedical Library and Informatics Review Committee (BLR)
Program Officer
Sim, Hua-Chuan
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Massachusetts General Hospital
United States
Zip Code
Raisaro, Jean Louis; Klann, Jeffrey G; Wagholikar, Kavishwar B et al. (2018) Feasibility of Homomorphic Encryption for Sharing I2B2 Aggregate-Level Data in the Cloud. AMIA Jt Summits Transl Sci Proc 2017:176-185
Wagholikar, Kavishwar B; Dessai, Pralav; Sanz, Javier et al. (2018) Implementation of informatics for integrating biology and the bedside (i2b2) platform as Docker containers. BMC Med Inform Decis Mak 18:66
Wagholikar, Kavishwar B; Mendis, Michael; Dessai, Pralav et al. (2018) Automating Installation of the Integrating Biology and the Bedside (i2b2) Platform. Biomed Inform Insights 10:1178222618777749
Wagholikar, Kavishwar B; Fischer, Christina M; Goodson, Alyssa et al. (2018) Extraction of Ejection Fraction from Echocardiography Notes for Constructing a Cohort of Patients having Heart Failure with reduced Ejection Fraction (HFrEF). J Med Syst 42:209
Klann, Jeffrey G; Phillips, Lori C; Herrick, Christopher et al. (2018) Web services for data warehouses: OMOP and PCORnet on i2b2. J Am Med Inform Assoc 25:1331-1338
Ravikumar, K E; MacLaughlin, Kathy L; Scheitel, Marianne R et al. (2018) Improving the Accuracy of a Clinical Decision Support System for Cervical Cancer Screening and Surveillance. Appl Clin Inform 9:62-71
Wagholikar, Kavishwar B; Mandel, Joshua C; Klann, Jeffery G et al. (2017) SMART-on-FHIR implemented over i2b2. J Am Med Inform Assoc 24:398-402
Weng, Wei-Hung; Wagholikar, Kavishwar B; McCray, Alexa T et al. (2017) Medical subdomain classification of clinical notes using a machine learning-based natural language processing approach. BMC Med Inform Decis Mak 17:155
Wagholikar, Kavishwar B; Jain, Rahul; Oliveira, Eliel et al. (2017) Evolving Research Data Sharing Networks to Clinical App Sharing Networks. AMIA Jt Summits Transl Sci Proc 2017:302-307
Wagholikar, Kavishwar B; Hankey, Ronald A; Decker, Lindsay K et al. (2015) Evaluation of the effect of decision support on the efficiency of primary care providers in the outpatient practice. J Prim Care Community Health 6:54-60