Several recent studies have emphasized that alcoholics as well as subjects with a close family history of alcoholism may have differences in their resting EEG and/or event related potentials (ERPs) as well as an altered reaction to acute ethanol exposure when compared to matched controls. The goals of the studies outlined in the proposal are to extend these findings from human subject populations to the development of animal models where the cognitive, physiological and biological mechanisms which underlie these differences in electrophysiology can be explored. Studies are proposed utilizing ethanol preferring (p) adn non- preferring rats (NP). The use of these animals should provide a unique opportunity to develop electrophysiological measures of genetically influenced variables in a model of voluntary ethanol consumption. The goals of the proposed studies are: 1) to evaluate the differences in EEG and ERP response of P and NP rats 2) to investigated the electrophysiological responses to acute ethanol challenged in P and NP rats. 3) To evaluate the consequences of chronic alcoholization on EEG and ERP responses 4) to determine the electrophysiological correlates of ethanol self administration in P and NP rats 5) To test the EEG and ERP responses of P and NP rats to challenges of the GABA- benzodiazepine ionophore complex. These studies have the potential to identify clinically relevant encephalographic """"""""markers"""""""" of ethanol actions in addition to possibly identifying the cognitive, physiological and/or neurochemical mechanisms which may be antecedent to alcoholism or alcohol abuse.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
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Biochemistry, Physiology and Medicine Subcommittee (ALCB)
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Scripps Research Institute
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Sanchez-Alavez, Manuel; Wills, Derek N; Amodeo, Leslie et al. (2018) Effect of Gabapentin on Sleep and Event-Related Oscillations (EROs) in Rats Exposed to Chronic Intermittent Ethanol Vapor and Protracted Withdrawal. Alcohol Clin Exp Res 42:624-633
Sanchez-Alavez, Manuel; Nguyen, William; Mori, Simone et al. (2018) Time course of microglia activation and brain and blood cytokine/chemokine levels following chronic ethanol exposure and protracted withdrawal in rats. Alcohol 76:37-45
Amodeo, Leslie R; Wills, Derek N; Sanchez-Alavez, Manuel et al. (2018) Intermittent voluntary ethanol consumption combined with ethanol vapor exposure during adolescence increases drinking and alters other behaviors in adulthood in female and male rats. Alcohol 73:57-66
Ehlers, Cindy L; Sanchez-Alavez, Manuel; Wills, Derek (2018) Effect of gabapentin on sleep and delta and theta EEG power in adult rats exposed to chronic intermittent ethanol vapor and protracted withdrawal during adolescence. Psychopharmacology (Berl) 235:1783-1791
Amodeo, Leslie R; Wills, Derek N; Ehlers, Cindy L (2017) Acute low-level alcohol consumption reduces phase locking of event-related oscillations in rodents. Behav Brain Res 330:25-29
Amodeo, Leslie R; Kneiber, Diana; Wills, Derek N et al. (2017) Alcohol drinking during adolescence increases consumptive responses to alcohol in adulthood in Wistar rats. Alcohol 59:43-51
Sanchez-Alavez, Manuel; Ehlers, Cindy L (2016) Event-related oscillations (ERO) during an active discrimination task: Effects of lesions of the nucleus basalis magnocellularis. Int J Psychophysiol 103:53-61
Ehlers, Cindy L; Desikan, Anita; Wills, Derek N (2014) Event-related potential responses to the acute and chronic effects of alcohol in adolescent and adult Wistar rats. Alcohol Clin Exp Res 38:749-59
Desikan, Anita; Wills, Derek N; Ehlers, Cindy L (2014) Ontogeny and adolescent alcohol exposure in Wistar rats: open field conflict, light/dark box and forced swim test. Pharmacol Biochem Behav 122:279-85
Sanchez-Alavez, Manuel; Robledo, Patricia; Wills, Derek N et al. (2014) Cholinergic modulation of event-related oscillations (ERO). Brain Res 1559:11-25

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