Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA081064-02
Application #
6174113
Study Section
Metabolic Pathology Study Section (MEP)
Program Officer
Kopelovich, Levy
Project Start
1999-04-01
Project End
2002-03-31
Budget Start
2000-04-01
Budget End
2001-03-31
Support Year
2
Fiscal Year
2000
Total Cost
$242,194
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Organized Research Units
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Li, Wei; Peng, Cong; Lee, Mee-Hyun et al. (2013) TRAF4 is a critical molecule for Akt activation in lung cancer. Cancer Res 73:6938-50
Lee, Mee-Hyun; Huang, Zunnan; Kim, Dong Joon et al. (2013) Direct targeting of MEK1/2 and RSK2 by silybin induces cell-cycle arrest and inhibits melanoma cell growth. Cancer Prev Res (Phila) 6:455-65
Liu, Kangdong; Yu, Donghoon; Cho, Yong-Yeon et al. (2013) Sunlight UV-induced skin cancer relies upon activation of the p38ýý signaling pathway. Cancer Res 73:2181-8
Xie, Hua; Lee, Mee-Hyun; Zhu, Feng et al. (2013) Discovery of the novel mTOR inhibitor and its antitumor activities in vitro and in vivo. Mol Cancer Ther 12:950-8
Li, Jixia; Malakhova, Margarita; Mottamal, Madhusoodanan et al. (2012) Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer Res 72:260-70
Oi, Naomi; Chen, Hanyong; Ok Kim, Myoung et al. (2012) Taxifolin suppresses UV-induced skin carcinogenesis by targeting EGFR and PI3K. Cancer Prev Res (Phila) 5:1103-14
Li, Shengqing; Bode, Ann M; Zhu, Feng et al. (2011) TRPV1-antagonist AMG9810 promotes mouse skin tumorigenesis through EGFR/Akt signaling. Carcinogenesis 32:779-85
Li, Tingting; Zhang, Jishuai; Zhu, Feng et al. (2011) P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation. Carcinogenesis 32:659-66
Kim, Jong-Eun; Lee, Dong-Eun; Lee, Ki Won et al. (2011) Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. Cancer Prev Res (Phila) 4:582-91
Kim, Dong Joon; Reddy, Kanamata; Kim, Myoung Ok et al. (2011) (3-Chloroacetyl)-indole, a novel allosteric AKT inhibitor, suppresses colon cancer growth in vitro and in vivo. Cancer Prev Res (Phila) 4:1842-51

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