A series of animal studies are proposed to examine the consequences of different drinking initiation procedures upon later ethanol use. In prior experiments in our laboratory, three distinct theoretical models have been developed that all result in successful ethanol reinforced behavior. However, no attempts have been made to determine if any of these different models result in differential drinking in chronic or stress situations. As well, the role of alcohol preference has not been examined in these models. The proposed experiments will test these hypothesis and use the results to make predictions concerning adolescent drinking. Prevention models could be suggested that would be aimed at reducing risk that may result from certain types of drinking initiation experiences.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA006845-03
Application #
3110226
Study Section
Alcohol Biomedical Research Review Committee (ALCB)
Project Start
1986-03-01
Project End
1989-02-28
Budget Start
1988-03-01
Budget End
1989-02-28
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
Schools of Arts and Sciences
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Samson, Herman H; Cunningham, Christopher L; Czachowski, Cristine L et al. (2004) Devaluation of ethanol reinforcement. Alcohol 32:203-12
Samson, Herman H; Chappell, Ann M (2004) Effects of raclopride in the core of the nucleus accumbens on ethanol seeking and consumption: the use of extinction trials to measure seeking. Alcohol Clin Exp Res 28:544-9
Czachowski, Cristine L; Legg, Brooke H; Samson, Herman H (2003) Assessment of sucrose and ethanol reinforcement: the across-session breakpoint procedure. Physiol Behav 78:51-9
Samson, Herman H; Chappell, Ann (2003) Dopaminergic involvement in medial prefrontal cortex and core of the nucleus accumbens in the regulation of ethanol self-administration: a dual-site microinjection study in the rat. Physiol Behav 79:581-90
Samson, Herman H; Czachowski, Cristine L; Chappell, Ann et al. (2003) Measuring the appetitive strength of ethanol: use of an extinction trial procedure. Alcohol 31:77-86
Samson, Herman H; Czachowski, Cristine L (2003) Behavioral measures of alcohol self-administration and intake control: rodent models. Int Rev Neurobiol 54:107-43
Samson, Herman H; Chappell, Ann (2003) Failure of a schedule-induction procedure to increase ethanol intake in an established limited-access self-administration condition. Alcohol 31:161-5
Czachowski, Cristine L; Santini, Lindsay A; Legg, Brooke H et al. (2002) Separate measures of ethanol seeking and drinking in the rat: effects of remoxipride. Alcohol 28:39-46
Samson, Herman H; Chappell, Ann (2002) Reinstatement of ethanol seeking responding after ethanol self-administration. Alcohol 26:95-101
Sim-Selley, Laura J; Sharpe, Amanda L; Vogt, Leslie J et al. (2002) Effect of ethanol self-administration on mu- and delta-opioid receptor-mediated G-protein activity. Alcohol Clin Exp Res 26:688-94

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