Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA007040-09
Application #
2043654
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1987-07-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Wu, G; Miller, K W (1994) Ethanol enhances agonist-induced fast desensitization in nicotinic acetylcholine receptors. Biochemistry 33:9085-91
Wu, G; Tonner, P H; Miller, K W (1994) Ethanol stabilizes the open channel state of the Torpedo nicotinic acetylcholine receptor. Mol Pharmacol 45:102-8
Abadji, V; Raines, D E; Dalton, L A et al. (1994) Lipid-protein interactions and protein dynamics in vesicles containing the nicotinic acetylcholine receptor: a study with ethanol. Biochim Biophys Acta 1194:25-34
Wood, S C; Hill, W A; Miller, K W (1993) Cycloalkanemethanols discriminate between volume- and length-dependent loss of activity of alkanols at the Torpedo nicotinic acetylcholine receptor. Mol Pharmacol 44:1219-26
Dalton, L A; Miller, K W (1993) Trans-unsaturated lipid dynamics: modulation of dielaidoylphosphatidylcholine acyl chain motion by ethanol. Biophys J 65:1620-31
Abadji, V C; Raines, D E; Watts, A et al. (1993) The effect of general anesthetics on the dynamics of phosphatidylcholine-acetylcholine receptor interactions in reconstituted vesicles. Biochim Biophys Acta 1147:143-53
Tonner, P H; Wood, S C; Miller, K W (1992) Can nicotine self-inhibition account for its low efficacy at the nicotinic acetylcholine receptor from Torpedo? Mol Pharmacol 42:890-7
Wood, S C; Forman, S A; Miller, K W (1991) Short chain and long chain alkanols have different sites of action on nicotinic acetylcholine receptor channels from Torpedo. Mol Pharmacol 39:332-8
Miller, K W; Wood, S C; Forman, S A et al. (1991) The nicotinic acetylcholine receptor in its membrane environment. Ann N Y Acad Sci 625:600-15
Koski, G; Lawrence, K; Righi, D (1991) Ethanol-induced inhibition of carbachol-stimulated uptake of calcium in PC12 pheochromocytoma cells. Neuropharmacology 30:267-74

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