New Diagnostic Markers of Alcohol Abuse

Lumeng, Lawrence

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
• Type: Research Project (R01)
• Project #: 5R01AA007647-02
• Application #: 3111470
• Study Section: (SRCA)
• Project Start: 1987-09-01
• Project End: 1992-08-31
• Budget Start: 1988-09-01
• Budget End: 1989-08-31
• Support Year: 2
• Fiscal Year: 1988

Institution

• Name: Indiana University-Purdue University at Indianapolis
• Type: Schools of Medicine
• DUNS #: 005436803
• City: Indianapolis
• State: IN
• Country: United States
• Zip Code: 46202

Publications

Zhu, Y; Fillenwarth, M J; Crabb, D et al. (1996) Identification of the 37-kd rat liver protein that forms an acetaldehyde adduct in vivo as delta 4-3-ketosteroid 5 beta-reductase. Hepatology 23:115-22

Lin, R C; Dai, J; Lumeng, L et al. (1995) Serum low density lipoprotein of alcoholic patients is chemically modified in vivo and induces apolipoprotein E synthesis by macrophages. J Clin Invest 95:1979-86

Lin, R C; Smith, J B; Radtke, D B et al. (1995) Structural analysis of peptide-acetaldehyde adducts by mass spectrometry and production of antibodies directed against nonreduced protein-acetaldehyde adducts. Alcohol Clin Exp Res 19:314-9

Lin, R C; Lumeng, L (1991) Effect of chronic ethanol feeding on high density lipoprotein subfractions in rats. Alcohol Clin Exp Res 15:207-11

Lin, R C; Lumeng, L (1990) Formation of the 37KD protein-acetaldehyde adduct in liver during alcohol treatment is dependent on alcohol dehydrogenase activity. Alcohol Clin Exp Res 14:766-70

Lin, R C; Lumeng, L; Shahidi, S et al. (1990) Protein-acetaldehyde adducts in serum of alcoholic patients. Alcohol Clin Exp Res 14:438-43

Lin, R C; Fillenwarth, M J; Minter, R et al. (1990) Formation of the 37-kD protein-acetaldehyde adduct in primary cultured rat hepatocytes exposed to alcohol. Hepatology 11:401-7

Lin, R C; Lumeng, L (1989) Further studies on the 37 kD liver protein-acetaldehyde adduct that forms in vivo during chronic alcohol ingestion. Hepatology 10:807-14