Immune Response to Acetaldehyde Adducts

Klassen, Lynell W.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
• Type: Research Project (R01)
• Project #: 5R01AA007818-06
• Application #: 2044154
• Study Section: Biochemistry, Physiology and Medicine Subcommittee (ALCB)
• Project Start: 1989-04-01
• Project End: 1998-05-31
• Budget Start: 1996-06-01
• Budget End: 1997-05-31
• Support Year: 6
• Fiscal Year: 1996

Institution

• Name: University of Nebraska Medical Center
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• City: Omaha
• State: NE
• Country: United States
• Zip Code: 68198

Publications

Thiele, Geoffrey M; Klassen, Lynell W; Tuma, Dean J (2008) Formation and immunological properties of aldehyde-derived protein adducts following alcohol consumption. Methods Mol Biol 447:235-57

Duryee, Michael J; Freeman, Thomas L; Willis, Monte S et al. (2005) Scavenger receptors on sinusoidal liver endothelial cells are involved in the uptake of aldehyde-modified proteins. Mol Pharmacol 68:1423-30

Duryee, Michael J; Klassen, Lynell W; Freeman, Thomas L et al. (2004) Lipopolysaccharide is a cofactor for malondialdehyde-acetaldehyde adduct-mediated cytokine/chemokine release by rat sinusoidal liver endothelial and Kupffer cells. Alcohol Clin Exp Res 28:1931-8

Duryee, Michael J; Willis, Monte S; Freeman, Thomas L et al. (2004) Mechanisms of alcohol liver damage: aldehydes, scavenger receptors, and autoimmunity. Front Biosci 9:3145-55

Willis, Monte S; Klassen, Lynell W; Carlson, Deborah L et al. (2004) Malondialdehyde-acetaldehyde haptenated protein binds macrophage scavenger receptor(s) and induces lysosomal damage. Int Immunopharmacol 4:885-99

Willis, Monte S; Thiele, Geoffrey M; Tuma, Dean J et al. (2003) T cell proliferative responses to malondialdehyde-acetaldehyde haptenated protein are scavenger receptor mediated. Int Immunopharmacol 3:1381-99

Duryee, Michael J; Klassen, Lynell W; Freeman, Thomas L et al. (2003) Chronic ethanol consumption impairs receptor-mediated endocytosis of MAA-modified albumin by liver endothelial cells. Biochem Pharmacol 66:1045-54

Thiele, Geoffrey M; Szabo, Gyongyi; Kovacs, Elizabeth J et al. (2002) Modulation of immunity and viral-host interactions by alcohol. Alcohol Clin Exp Res 26:1897-908

Willis, Monte S; Klassen, Lynell W; Tuma, Dean J et al. (2002) In vitro exposure to malondialdehyde-acetaldehyde adducted protein inhibits cell proliferation and viability. Alcohol Clin Exp Res 26:158-64

Willis, Monte S; Klassen, Lynell W; Tuma, Dean J et al. (2002) Adduction of soluble proteins with malondialdehyde-acetaldehyde (MAA) induces antibody production and enhances T-cell proliferation. Alcohol Clin Exp Res 26:94-106