We propose to 30vestigate neurobiological indicators (auditory and visual Event-R31ated Potentials, personality variants, iconic memory, vigila32e, Category Errors) of alcoholism risk in alcoholic women selected33or absence of drug dependence and other psychiatric illness, and their relatives (parents, siblings, children, and siblings' children) through use of control families without alcoholism or psychiatric illness. Secondly, we will study the transmission of alcoholism within families of alcoholic women during presence or absence of alcoholism of relatives to determine if: (1) alcoholism is a heterogeneous disorder in women; (2) the mode of transmission is multifactorial or gives evidence for a major gene as well; and (3) path analytic techniques give evidence for specific multifactorial inheritance (i.e., the Environmental Model, Daughter Effects, Cross Sex Effects). We propose to ascertain nuclear families through a pair of female alcoholic probands, providing a large number of nuclear families with which to uncover possible neurobiological indicators of risk. Extended pedigrees will provide data for path and segregation analysis. From these analyses, we can describe the mode of inheritance and quantify the lifetime risk for developing alcoholism among these children of alcoholic mothers. With follow-up during subsequent investigations, we can confirm whether or not our predictions for specific children are correct. Further exploration of neurobehavioral deficits in children of alcoholics will be accomplished using the children's psychiatric status, measures of ERP (both auditory and visual are currently implemented in our laboratory), vigilance, iconic memory, and neurological functioning including static ataxia.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Project (R01)
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Biochemistry, Physiology and Medicine Subcommittee (ALCB)
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Rosalind Franklin University
Schools of Medicine
North Chicago
United States
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Aller, C B; Ehmann, S; Gilman-Sachs, A et al. (1997) Flow cytometric analysis of glucose transport by rat brain cells. Cytometry 27:262-8
Jacobs, D B; Mandelin 2nd, A M; Giordano, T et al. (1996) AUUUA-specific mRNA binding proteins in astrocytes. Life Sci 58:2083-9
Singh, L D; Singh, S P; Handa, R K et al. (1996) Effects of ethanol on GLUT1 protein and gene expression in rat astrocytes. Metab Brain Dis 11:343-57
Singh, S P; Ehmann, S; Snyder, A K (1996) Ethanol-induced changes in insulin-like growth factors and IGF gene expression in the fetal brain. Proc Soc Exp Biol Med 212:349-54
Srivenugopal, K; Singh, S P; Yuan, X H et al. (1994) Differential removal of insulin-like growth factor binding proteins in rat serum by solvent extraction procedures. Experientia 50:451-5
Singh, S P; Srivenugopal, K S; Ehmann, S et al. (1994) Insulin-like growth factors (IGF-I and IGF-II), IGF-binding proteins, and IGF gene expression in the offspring of ethanol-fed rats. J Lab Clin Med 124:183-92
Snyder, A K; Singh, S P; Ehmann, S (1992) Effects of ethanol on DNA, RNA, and protein synthesis in rat astrocyte cultures. Alcohol Clin Exp Res 16:295-300
Snyder, A K; Jiang, F; Singh, S P (1992) Effects of ethanol on glucose utilization by cultured mammalian embryos. Alcohol Clin Exp Res 16:466-70
Singh, S P; Snyder, A K; Eman, S (1990) Effects of ethanol on hexose uptake by cultured rat brain cells. Alcohol Clin Exp Res 14:741-5