Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
2R01AA009013-04A3
Application #
2045049
Study Section
Special Emphasis Panel (ZRG4-ALTX-3)
Project Start
1991-09-27
Project End
2001-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Psychology
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Kralic, Jason E; Sidler, Corinne; Parpan, Franziska et al. (2006) Compensatory alteration of inhibitory synaptic circuits in cerebellum and thalamus of gamma-aminobutyric acid type A receptor alpha1 subunit knockout mice. J Comp Neurol 495:408-21
Kralic, Jason E; Criswell, Hugh E; Osterman, Jessica L et al. (2005) Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice. J Clin Invest 115:774-9
Kumar, Sandeep; Fleming, Rebekah L; Morrow, A Leslie (2004) Ethanol regulation of gamma-aminobutyric acid A receptors: genomic and nongenomic mechanisms. Pharmacol Ther 101:211-26
Kralic, J E; Wheeler, M; Renzi, K et al. (2003) Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics. J Pharmacol Exp Ther 305:600-7
Overstreet, David H; Kralic, Jason E; Morrow, A Leslie et al. (2003) NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists. Pharmacol Biochem Behav 75:619-25
Kumar, S; Kralic, J E; O'Buckley, T K et al. (2003) Chronic ethanol consumption enhances internalization of alpha1 subunit-containing GABAA receptors in cerebral cortex. J Neurochem 86:700-8
Kumar, Sandeep; Sieghart, Werner; Morrow, A Leslie (2002) Association of protein kinase C with GABA(A) receptors containing alpha1 and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption. J Neurochem 82:110-7
Kralic, J E; Korpi, E R; O'Buckley, T K et al. (2002) Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice. J Pharmacol Exp Ther 302:1037-45
Grobin, A C; Matthews, D B; Montoya, D et al. (2001) Age-related differences in neurosteroid potentiation of muscimol-stimulated 36Cl(-) flux following chronic ethanol treatment. Neuroscience 105:547-52
Papadeas, S; Grobin, A C; Morrow, A L (2001) Chronic ethanol consumption differentially alters GABA(A) receptor alpha1 and alpha4 subunit peptide expression and GABA(A) receptor-mediated 36 Cl(-) uptake in mesocorticolimbic regions of rat brain. Alcohol Clin Exp Res 25:1270-5

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