Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
2R01AA009526-04
Application #
2045761
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1993-04-01
Project End
2001-03-31
Budget Start
1996-06-01
Budget End
1997-03-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Southern California
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Feng, Guoping; Kaplowitz, Neil (2002) Mechanism of staurosporine-induced apoptosis in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol 282:G825-34
Ardite, E; Sans, M; Panes, J et al. (2000) Replenishment of glutathione levels improves mucosal function in experimental acute colitis. Lab Invest 80:735-44
Roman, J; Gimenez, A; Lluis, J M et al. (2000) Enhanced DNA binding and activation of transcription factors NF-kappa B and AP-1 by acetaldehyde in HEPG2 cells. J Biol Chem 275:14684-90
Garcia-Ruiz, C; Colell, A; Paris, R et al. (2000) Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation. FASEB J 14:847-58
Feng, G; Kaplowitz, N (2000) Colchicine protects mice from the lethal effect of an agonistic anti-Fas antibody. J Clin Invest 105:329-39
Ardite, E; Ramos, C; Rimola, A et al. (1999) Hepatocellular oxidative stress and initial graft injury in human liver transplantation. J Hepatol 31:921-7
Bosch-Morell, F; Martinez-Soriano, F; Colell, A et al. (1998) Chronic ethanol feeding induces cellular antioxidants decrease and oxidative stress in rat peripheral nerves. Effect of S-adenosyl-L-methionine and N-acetyl-L-cysteine. Free Radic Biol Med 25:365-8
Colell, A; Garcia-Ruiz, C; Miranda, M et al. (1998) Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology 115:1541-51
Fernandez-Checa, J C; Garcia-Ruiz, C; Colell, A et al. (1998) Oxidative stress: role of mitochondria and protection by glutathione. Biofactors 8:7-11
Ardite, E; Panes, J; Miranda, M et al. (1998) Effects of steroid treatment on activation of nuclear factor kappaB in patients with inflammatory bowel disease. Br J Pharmacol 124:431-3

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