Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA009731-02
Application #
2045989
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1995-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
009214214
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Collins, Xixuan H; Harmon, Shawn D; Kaduce, Terry L et al. (2005) Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4. J Biol Chem 280:33157-64
Molotkov, Andrei; Ghyselinck, Norbert B; Chambon, Pierre et al. (2004) Opposing actions of cellular retinol-binding protein and alcohol dehydrogenase control the balance between retinol storage and degradation. Biochem J 383:295-302
Galter, Dagmar; Carmine, Andrea; Buervenich, Silvia et al. (2003) Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain. Eur J Biochem 270:1316-26
Vaglenova, Julia; Martinez, Susana E; Porte, Sergio et al. (2003) Expression, localization and potential physiological significance of alcohol dehydrogenase in the gastrointestinal tract. Eur J Biochem 270:2652-62
Duester, Gregg; Mic, Felix A; Molotkov, Andrei (2003) Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid. Chem Biol Interact 143-144:201-10
Molotkov, Andrei; Fan, Xiaohong; Deltour, Louise et al. (2002) Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3. Proc Natl Acad Sci U S A 99:5337-42
Molotkov, Andrei; Fan, Xiaohong; Duester, Gregg (2002) Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3. Eur J Biochem 269:2607-12
Chou, Chu-Fang; Lai, Ching-Long; Chang, Yen-Chun et al. (2002) Kinetic mechanism of human class IV alcohol dehydrogenase functioning as retinol dehydrogenase. J Biol Chem 277:25209-16
Molotkov, Andrei; Duester, Gregg (2002) Retinol/ethanol drug interaction during acute alcohol intoxication in mice involves inhibition of retinol metabolism to retinoic acid by alcohol dehydrogenase. J Biol Chem 277:22553-7
Molotkov, Andrei; Deltour, Louise; Foglio, Mario H et al. (2002) Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice. J Biol Chem 277:13804-11

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