Alcohol Liver Disease and S-Adenosylmethionine

McClain, Craig J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
• Type: Research Project (R01)
• Project #: 5R01AA010496-07
• Application #: 6629594
• Study Section: Alcohol and Toxicology Subcommittee 4 (ALTX)
• Program Officer: Russo, Denise A
• Project Start: 1996-03-01
• Project End: 2006-05-31
• Budget Start: 2003-06-01
• Budget End: 2004-05-31
• Support Year: 7
• Fiscal Year: 2003
• Total Cost: $286,000

Institution

• Name: University of Louisville
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 057588857
• City: Louisville
• State: KY
• Country: United States
• Zip Code: 40292

Publications

Smart, Laura; Gobejishvili, Leila; Crittenden, Neil et al. (2013) Alcoholic Hepatitis: Steroids vs. Pentoxifylline. Curr Hepat Rep 12:59-65

Kirpich, Irina A; Feng, Wenke; Wang, Yuhua et al. (2012) The type of dietary fat modulates intestinal tight junction integrity, gut permeability, and hepatic toll-like receptor expression in a mouse model of alcoholic liver disease. Alcohol Clin Exp Res 36:835-46

Liu, Yanlong; Wang, Chunhong; Wang, Yuhua et al. (2012) Cobalt chloride decreases fibroblast growth factor-21 expression dependent on oxidative stress but not hypoxia-inducible factor in Caco-2 cells. Toxicol Appl Pharmacol 264:212-21

Gaetke, Lisa M; McClain, Craig J; Toleman, C Jean et al. (2010) Yogurt protects against growth retardation in weanling rats fed diets high in phytic acid. J Nutr Biochem 21:147-52

Kirpich, Irina A; Solovieva, Natalia V; Leikhter, Svetlana N et al. (2008) Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study. Alcohol 42:675-82

Gobejishvili, Leila; Barve, Shirish; Joshi-Barve, Swati et al. (2008) Enhanced PDE4B expression augments LPS-inducible TNF expression in ethanol-primed monocytes: relevance to alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 295:G718-24

Chang, Weiyuan; McClain, Craig J; Liu, Marcia C et al. (2008) Effects of 2(RS)-n-propylthiazolidine-4(R)-carboxylic acid on 4-hydroxy-2-nonenal-induced apoptotic T cell death. J Nutr Biochem 19:184-92

de Villiers, Willem J S; Song, Zhenyuan; Nasser, Munira S et al. (2007) 4-Hydroxynonenal-induced apoptosis in rat hepatic stellate cells: mechanistic approach. J Gastroenterol Hepatol 22:414-22

Cave, Matthew; Deaciuc, Ion; Mendez, Christian et al. (2007) Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition. J Nutr Biochem 18:184-95

Purohit, Vishnudutt; Abdelmalek, Manal F; Barve, Shirish et al. (2007) Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am J Clin Nutr 86:14-24