Sequence Determinants of the Dominant Effect of ALDH2*2

Crabb, David W.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
• Type: Research Project (R01)
• Project #: 5R01AA010525-02
• Application #: 2047177
• Study Section: Special Emphasis Panel (SRCA (57))
• Project Start: 1995-05-01
• Project End: 1999-04-30
• Budget Start: 1996-05-01
• Budget End: 1997-04-30
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: Indiana University-Purdue University at Indianapolis
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 005436803
• City: Indianapolis
• State: IN
• Country: United States
• Zip Code: 46202

Publications

Matsumoto, Michinaga; Cyganek, Izabela; Sanghani, Paresh C et al. (2011) Ethanol metabolism by HeLa cells transduced with human alcohol dehydrogenase isoenzymes: control of the pathway by acetaldehyde concentration. Alcohol Clin Exp Res 35:28-38

Xiao, Q; Weiner, H; Crabb, D (1997) Studies on the dominant negative effect of the ALDH2*2 allele. Adv Exp Med Biol 414:187-94

Xiao, Q; Weiner, H; Crabb, D W (1996) The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. J Clin Invest 98:2027-32