Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
1R01AA010795-01A1
Application #
2047440
Study Section
Special Emphasis Panel (ZRG4-ALTX-1)
Project Start
1996-07-01
Project End
2001-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Purdue University
Department
Biochemistry
Type
Schools of Earth Sciences/Natur
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Mukhopadhyay, Abhijit; Wei, Baoxian; Weiner, Henry (2013) Mitochondrial NAD dependent aldehyde dehydrogenase either from yeast or human replaces yeast cytoplasmic NADP dependent aldehyde dehydrogenase for the aerobic growth of yeast on ethanol. Biochim Biophys Acta 1830:3391-8
Mukhopadhyay, Abhijit; Weiner, Henry (2007) Delivery of drugs and macromolecules to mitochondria. Adv Drug Deliv Rev 59:729-38
Mukhopadhyay, Abhijit; Yang, Chun-song; Wei, Baoxian et al. (2007) Precursor protein is readily degraded in mitochondrial matrix space if the leader is not processed by mitochondrial processing peptidase. J Biol Chem 282:37266-75
Mukhopadhyay, Abhijit; Yang, Chun-Song; Weiner, Henry (2006) Binding of mitochondrial leader sequences to Tom20 assessed using a bacterial two-hybrid system shows that hydrophobic interactions are essential and that some mutated leaders that do not bind Tom20 can still be imported. Protein Sci 15:2739-48
Mukhopadhyay, Abhijit; Zullo, Steven J; Weiner, Henry (2006) Factors that might affect the allotopic replacement of a damaged mitochondrial DNA-encoded protein. Rejuvenation Res 9:182-90
Mukhopadhyay, A; Ni, L; Yang, C-S et al. (2005) Bacterial signal peptide recognizes HeLa cell mitochondrial import receptors and functions as a mitochondrial leader sequence. Cell Mol Life Sci 62:1890-9
Mukhopadhyay, Abhijit; Ni, Li; Weiner, Henry (2004) A co-translational model to explain the in vivo import of proteins into HeLa cell mitochondria. Biochem J 382:385-92
Mukhopadhyay, Abhijit; Heard, Thomas S; Wen, Xiaohui et al. (2003) Location of the actual signal in the negatively charged leader sequence involved in the import into the mitochondrial matrix space. J Biol Chem 278:13712-8
Mukhopadhyay, Abhijit; Avramova, Larisa V; Weiner, Henry (2002) Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins. Arch Biochem Biophys 400:97-104
Yang, Chun-Song; Weiner, Henry (2002) Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol. Arch Biochem Biophys 400:105-10

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