Extensive research has documented strong associations between alcohol and tobacco use. Various mechanisms have been invoked to explain a dual addiction to alcohol and nicotine, as well as the strong association between alcohol and tobacco intake across a range of consumption levels. Among them, behavioral models assert that associative learning occurs as a consequence of the frequent contemporaneous use of these two drugs. Using these models as a conceptual framework, preliminary work in our laboratory has demonstrated that alcohol cues and smoking cues elicit both strong cravings to drink alcohol and cravings to smoke (i.e., """"""""cross-cue reactivity"""""""") in alcoholic smokers. Similar patterns, albeit to a lesser extent, were observed in alcoholic nonsmokers and non-alcoholic smokers. The work proposed in this competitive continuation application extends this line of research by examining the separate and combined influence of alcohol/nicotine intake and salient substance cues on a broad range of subjective, physiological, and behavioral reactions. Using primarily within-subjects design features and established placebo control drug administration methods, Study 1 will investigate cravings and physiological reactivity to pictorial alcohol, smoking, and neutral cues in the presence of alcohol and/or nicotine. Study 2 will further examine the influence of alcohol and nicotine drug/cue manipulations on alcohol self administration. Both studies will examine subjects across a broad range of alcohol and tobacco use patterns, and statistical models will evaluate the extent to which pharmacological and cue based effects are influenced by individual differences in alcohol and tobacco intake. Overall, the proposed research will provide valuable basic data regarding the separate and combined influences of alcohol, nicotine, and relevant cues on multidimensional aspects of alcohol and smoking cue reactivity. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA011157-08
Application #
7158605
Study Section
Special Emphasis Panel (ZRG1-BBBP-C (03))
Program Officer
Fertig, Joanne
Project Start
1998-02-01
Project End
2010-11-30
Budget Start
2006-12-01
Budget End
2007-11-30
Support Year
8
Fiscal Year
2007
Total Cost
$316,798
Indirect Cost
Name
H. Lee Moffitt Cancer Center & Research Institute
Department
Type
DUNS #
139301956
City
Tampa
State
FL
Country
United States
Zip Code
33612
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Oliver, Jason A; Blank, Melissa D; Van Rensburg, Kate Janse et al. (2013) Nicotine interactions with low-dose alcohol: pharmacological influences on smoking and drinking motivation. J Abnorm Psychol 122:1154-65
Drobes, David J; Carter, Ashlee C; Goldman, Mark S (2009) Alcohol expectancies and reactivity to alcohol-related and affective cues. Exp Clin Psychopharmacol 17:1-9