The proposed experiments will continue to assess consequences of early exposure to ethanol for responsiveness to ethanol later in development. In view of epidemiological evidence for relatively frequent exposure to ethanol among human infants as well as fetuses, and clinical evidence that prenatal exposure to ethanol in humans predicts ethanol abuse in adolescence and early adulthood, the proposed experiments are relevant to issues of adolescent initiation to ethanol as well as more proximal consequences of early ethanol exposure. Three circumstances of early ethanol exposure to be studied are in the form of three specific aims: (1) To examine consequences of fetal processing of ethanol's chemosensory attributes and those of a learned association between them and ethanol's pharmacological effects; (2) To determine consequences of postnatal nursing experience involving ethanol for subsequent responsiveness to ethanol's chemosensory attributes, sensitivity to ethanol's postabsorptive effects and self-administration of ethanol; (3) To assess longitudinally the interactive consequences of prenatal and early postnatal exposure to ethanol for subsequent ethanol sensitivity and learning about ethanol during the preadolescent and adolescent periods. Experiments will apply techniques developed and previously employed in our laboratories, providing a combination of relatively new methods of treatment and assessment with methods used for many years. The experiments will include systematic assessment of: fetal associative learning supported by the reinforcing effects of ethanol during prenatal ethanol exposure and the consequences for postnatal responsiveness to ethanol; the consequences of ethanol exposure during nursing for later responsiveness to ethanol, novel environments and motor challenges; and conditioned and unconditioned effects of combined ethanol exposure as a fetus and as a nursing infant on later learning about ethanol, acceptance of ethanol and response to socially induced acceptance of ethanol. Theoretical orientation for considering the consequences of early ethanol exposure is focused on learning induced by that exposure and motivational content of related early memories. Special concern is given to specific temporal windows following ethanol exposure that yield memories of specific motivational associates, and the effect of multiple, potentially interactive exposures to ethanol for later patterns of ethanol recognition and acceptance ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA011960-10
Application #
7343249
Study Section
Alcohol and Toxicology Subcommittee 4 (ALTX)
Program Officer
Witt, Ellen
Project Start
1998-09-15
Project End
2010-01-31
Budget Start
2008-02-01
Budget End
2010-01-31
Support Year
10
Fiscal Year
2008
Total Cost
$220,528
Indirect Cost
Name
State University of NY, Binghamton
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
090189965
City
Binghamton
State
NY
Country
United States
Zip Code
13902
Bordner, Kelly; Deak, Terrence (2015) Endogenous opioids as substrates for ethanol intake in the neonatal rat: The impact of prenatal ethanol exposure on the opioid family in the early postnatal period. Physiol Behav 148:100-10
Cullere, Marcela; Macchione, Ana Fabiola; Haymal, Beatriz et al. (2015) Neonatal sensitization to ethanol-induced breathing disruptions as a function of late prenatal exposure to the drug in the rat: modulatory effects of ethanol's chemosensory cues. Physiol Behav 139:412-22
Kamenetzky, Giselle V; Suárez, Andrea B; Pautassi, Ricardo M et al. (2015) Change in the hedonic value of an aversive stimulus in the presence of a pre-exposed odor. Physiol Behav 148:51-7
Miranda-Morales, Roberto Sebastián; Nizhnikov, Michael E; Waters, Dustin H et al. (2014) New evidence of ethanol's anxiolytic properties in the infant rat. Alcohol 48:367-74
Culleré, Marcela Elena; Spear, Norman E; Molina, Juan Carlos (2014) Prenatal ethanol increases sucrose reinforcement, an effect strengthened by postnatal association of ethanol and sucrose. Alcohol 48:25-33
Miranda-Morales, Roberto Sebastián; Nizhnikov, Michael E; Spear, Norman E (2014) Prenatal exposure to ethanol during late gestation facilitates operant self-administration of the drug in 5-day-old rats. Alcohol 48:19-23
Nizhnikov, Michael E; Pautassi, Ricardo M; Carter, Jenna M et al. (2014) Brief prenatal ethanol exposure alters behavioral sensitivity to the kappa opioid receptor agonist (U62,066E) and antagonist (Nor-BNI) and reduces kappa opioid receptor expression. Alcohol Clin Exp Res 38:1630-8
Fabio, María Carolina; Nizhnikov, Michael E; Spear, Norman E et al. (2014) Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats. Dev Psychobiol 56:574-83
March, Samanta M; Abate, Paula; Spear, Norman E et al. (2013) The role of acetaldehyde in ethanol reinforcement assessed by Pavlovian conditioning in newborn rats. Psychopharmacology (Berl) 226:491-9
Acevedo, María Belén; Nizhnikov, Michael E; Spear, Norman E et al. (2013) Ethanol-induced locomotor activity in adolescent rats and the relationship with ethanol-induced conditioned place preference and conditioned taste aversion. Dev Psychobiol 55:429-42

Showing the most recent 10 out of 98 publications