This is the second submission of a proposal which was initially reviewed in response to an RFA entitled """"""""Neurobiological Mechanisms of Adolescent Alcohol Abuse"""""""" (AA-99-002). We propose a 3 year cross sectional investigation to non-invasively examine the effects of alcohol use disorders (AUD) (defined as DSM-IV alcohol dependence or abuse) and posttraumatic stress disorder (PTSD) on hippocampal development in adolescents. The developing hippocampus may be particularly vulnerable to the toxic effects of alcohol. We have recently published our pilot investigation comparing medically healthy adolescents and young adults with AUD and age and sex matched controls on hippocampal volumes. We found a decrease in total hippocampal volume in AUD subjects compared with matched controls. A substantial percentage of adolescents with AUD are comorbid with PTSD secondary to a history of childhood physical and sexual abuse. Previous studies have suggested that childhood traumatic experiences, which lead to a diagnosis of PTSD, may have adverse effects of brain development. This study will therefore examine the main effect of AUD, the main effect of PTSD and the interaction of AUD and PTSD on adolescent hippocampal development. We hypothesize that AUD and PTSD both adversely effect hippocampal volume and hippocampal function. Recruitment, assessment, and administration of this investigation will occur primarily through the Pittsburgh Adolescent Alcohol Research Center (PAARC), an NIAAA Alcohol Research Center. Four adolescent groups will be compared: 1) AUD adolescents with PTSD (n=36), 2) AUD adolescents with PTSD (n=36), 3) adolescents with PTSD and with or without a current of lifetime diagnosis of AUD (n=36), and 4) age, sex, and sociodemographically matched healthy community control adolescents (n=3 6). This design will determine the effects of AUD while controlling for the effects of PTSD and environmental variables. In addition to examining the differences among these groups, the effects of AUD age of onset, AUD severity, as well as alcohol consumption quantity, frequency, and duration, on adolescent hippocampal development will also be examined.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
1R01AA012479-01A2
Application #
6333428
Study Section
Alcohol and Toxicology Subcommittee 4 (ALTX)
Program Officer
Witt, Ellen
Project Start
2001-07-01
Project End
2004-03-31
Budget Start
2001-07-01
Budget End
2002-03-31
Support Year
1
Fiscal Year
2001
Total Cost
$326,895
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Nooner, Kate B; Hooper, Stephen R; De Bellis, Michael D (2018) An examination of sex differences on neurocognitive functioning and behavior problems in maltreated youth. Psychol Trauma 10:435-443
Stave, Elise A; De Bellis, Michael D; Hooper, Steven R et al. (2017) Dimensions of Attention Associated With the Microstructure of Corona Radiata White Matter. J Child Neurol 32:458-466
Morey, Rajendra A; Haswell, Courtney C; Hooper, Stephen R et al. (2016) Amygdala, Hippocampus, and Ventral Medial Prefrontal Cortex Volumes Differ in Maltreated Youth with and without Chronic Posttraumatic Stress Disorder. Neuropsychopharmacology 41:791-801
Urger, Sacide E; De Bellis, Michael D; Hooper, Stephen R et al. (2015) The superior longitudinal fasciculus in typically developing children and adolescents: diffusion tensor imaging and neuropsychological correlates. J Child Neurol 30:9-20
De Bellis, Michael D; Hooper, Stephen R; Chen, Steven D et al. (2015) Posterior structural brain volumes differ in maltreated youth with and without chronic posttraumatic stress disorder. Dev Psychopathol 27:1555-76
Crozier, Joseph C; Wang, Lihong; Huettel, Scott A et al. (2014) Neural correlates of cognitive and affective processing in maltreated youth with posttraumatic stress symptoms: does gender matter? Dev Psychopathol 26:491-513
Marcus Jenkins, Jade V; Woolley, Donald P; Hooper, Stephen R et al. (2013) Direct and Indirect Effects of Brain Volume, Socioeconomic Status and Family Stress on Child IQ. J Child Adolesc Behav 1:
De Bellis, Michael D; Wang, Lihong; Bergman, Sara R et al. (2013) Neural mechanisms of risky decision-making and reward response in adolescent onset cannabis use disorder. Drug Alcohol Depend 133:134-45
Urger, Efsun; Debellis, Michael D; Hooper, Steven R et al. (2013) Influence of analysis technique on measurement of diffusion tensor imaging parameters. AJR Am J Roentgenol 200:W510-7
De Bellis, Michael D; Woolley, Donald P; Hooper, Stephen R (2013) Neuropsychological findings in pediatric maltreatment: relationship of PTSD, dissociative symptoms, and abuse/neglect indices to neurocognitive outcomes. Child Maltreat 18:171-83

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