This revised new investigator ROl application proposes an assessment of adult twin pairs, their full siblings, and parents ascertained via twins' participation in a recently completed survey of the Australian National Health and Medical Research Council '1989 cohort. The target sample will be: (1) a """"""""childhood abuse"""""""" (CA) group (N=500 families) in which at least one twin reported having experienced childhood sexual abuse (CSA), physical abuse (PA), or both; and (2) a """"""""control"""""""" group (N=500 families) in which neither twin reported a history of abuse, matched to the CA group on the basis of gender. zygosity, and age.
The specific aims of this investigation are:
AIM1 To examine parental alcoholism and other parental predictors of offspring CSA and PA, and the routes by which these associations are mediated.
AIM2 To use data from non-abused co-twins and siblings to control for family background risk factors to permit: (i) improved estimation of the risks for negative outcomes associated with CSA and PA; (ii) examination of routes by which these risks are mediated and moderated.
AIM3 To more comprehensively determine the contributions of CSA and PA, cluster B personality disorders, depression, and anxiety disorders, to the inheritance of alcohol dependence risk and to identify critical intervening variables.
These aims will be accomplished by better assessing childhood abuse and neglect history and additional Axis I and II diagnoses in previously interviewed adult twin pairs and by obtaining comprehensive assessments of parents and other siblings (Axis I and H psychopathology as well as childhood abuse and neglect). Despite the limitations of retrospective data, this study population offers important advantages: 1) data available from the recently completed, extensive assessment of twins including history of early home environment, traumatic events, drug use, and parental alcohol problems in addition to psychiatric diagnostic assessments; 2) families with a demonstrated history of cooperation including the twins' willingness to allow telephone assessment of questions about CSA and PA history; 3) an established relationship between twin reports of childhood abuse and parental alcohol problems; 4) very low frequency of abstinence and high mean levels of alcohol consumption suggest that hypothesized relationships are likely to be expressed; 5) a powerful twin sibship design; 6) an ability to generalize findings to the twin panel as a whole.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA013446-02
Application #
6654499
Study Section
Social Sciences, Nursing, Epidemiology and Methods 4 (SNEM)
Program Officer
Breslow, Rosalind
Project Start
2002-09-05
Project End
2007-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
2
Fiscal Year
2003
Total Cost
$480,211
Indirect Cost
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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Werner, K B; McCutcheon, V V; Challa, M et al. (2016) The association between childhood maltreatment, psychopathology, and adult sexual victimization in men and women: results from three independent samples. Psychol Med 46:563-73
Sartor, Carolyn E; Grant, Julia D; Lynskey, Michael T et al. (2012) Common heritable contributions to low-risk trauma, high-risk trauma, posttraumatic stress disorder, and major depression. Arch Gen Psychiatry 69:293-9
Sartor, Carolyn E; McCutcheon, Vivia V; Nelson, Elliot C et al. (2012) Investigating the association between childhood sexual abuse and alcohol use disorders in women: does it matter how we ask about sexual abuse? J Stud Alcohol Drugs 73:740-8
Zietsch, B P; Verweij, K J H; Heath, A C et al. (2012) Do shared etiological factors contribute to the relationship between sexual orientation and depression? Psychol Med 42:521-32
Bedi, Saaniya; Nelson, Elliot C; Lynskey, Michael T et al. (2011) Risk for suicidal thoughts and behavior after childhood sexual abuse in women and men. Suicide Life Threat Behav 41:406-15
McCutcheon, Vivia V; Sartor, Carolyn E; Pommer, Nicole E et al. (2010) Age at trauma exposure and PTSD risk in young adult women. J Trauma Stress 23:811-4
Nelson, Elliot C; Lynskey, Michael T; Heath, Andrew C et al. (2010) A family study of adult twins with and without a history of childhood abuse: stability of retrospective reports of maltreatment and associated family measures. Twin Res Hum Genet 13:121-30
McCutcheon, Vivia V; Heath, Andrew C; Nelson, Elliot C et al. (2010) Clustering of trauma and associations with single and co-occurring depression and panic attack over twenty years. Twin Res Hum Genet 13:57-65
Nelson, Elliot C; Agrawal, Arpana; Pergadia, Michele L et al. (2010) H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence. Addict Biol 15:1-11

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