Adolescents of middle school and high school age are at high risk for alcohol consumption. Nonhuman primates living in social groups provide an excellent model for the study of social influences on biobehavioral development in general and alcohol abuse problem more specifically. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) is interested in encouraging investigators with expertise in primate developmental biology and behavior to seek collaborations with established alcohol researchers to elucidate the neurobiological mechanisms of adolescent alcohol abuse and alcoholism. Herein we submit a revision of a model of biobehavioral development that focuses on the origins of individual differences in voluntary alcohol consumption in young socially housed bonnet macaque monkeys. Differences in early maternal care are suggested as one basis for differences in relative risk for consuming higher quantities of ethanol. Biomarkers of the activity of the serotonergic system (CSF 5HIAA and the prolactin response to fenfluramine) will be evaluated. Subjects will be selected on the basis of a polymorphism in the promoter region of the serotonin transporter protein gene that modulates serotonergic activity. Maternal care will be determined through observation of mother infant interactions during early development in social group reared macaque monkeys. We hypothesize that monkeys experiencing poor quality maternal care during development will demonstrate increased risk for the expression of aggressive and impulsive behavior patterns as adolescents. We hypothesize that these behavior patterns will be present in monkeys that voluntarily consume greater quantities of ethanol. Low serotonin will have an additive effect with low quality maternal care on levels of aggression, impulsivity, and alcohol consumption. We predict that adolescent monkeys evidencing higher aggressive and impulsive behavior patterns and low serotonin will show 1) increased rates of ethanol consumption under social conditions, 2) a greater increase in ethanol intake in response to a stressor, 3) higher probability that ethanol consumption will be associated with increased aggression when housed socially, and 4) attenuated soporific effects. Finally, involvement of the HPA axis in these relationships will be investigated as an exploratory goal.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
3R01AA013973-05S1
Application #
7859456
Study Section
Biobehavioral Regulation, Learning and Ethology Study Section (BRLE)
Program Officer
Witt, Ellen
Project Start
2009-07-15
Project End
2011-05-31
Budget Start
2009-07-15
Budget End
2011-05-31
Support Year
5
Fiscal Year
2009
Total Cost
$133,366
Indirect Cost
Name
University of Colorado Denver
Department
Psychiatry
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Laudenslager, Mark L (2014) ""Anatomy of an Illness"": control from a caregiver's perspective. Brain Behav Immun 36:1-8
Hopkins, William D; Meguerditchian, Adrien; Coulon, Olivier et al. (2014) Evolution of the central sulcus morphology in primates. Brain Behav Evol 84:19-30
Laudenslager, Mark L; Natvig, Crystal; Corcoran, Christopher A et al. (2013) The influences of perinatal challenge persist into the adolescent period in socially housed bonnet macaques (Macaca radiata). Dev Psychobiol 55:316-22
Bogart, Stephanie L; Mangin, Jean-Fran├žois; Schapiro, Steven J et al. (2012) Cortical sulci asymmetries in chimpanzees and macaques: a new look at an old idea. Neuroimage 61:533-41
Shively, Carol A; Willard, Stephanie L; Register, Thomas C et al. (2012) Aging and physical mobility in group-housed Old World monkeys. Age (Dordr) 34:1123-31
D'Anna-Hernandez, Kimberly L; Hoffman, Maria Camille; Zerbe, Gary O et al. (2012) Acculturation, maternal cortisol, and birth outcomes in women of Mexican descent. Psychosom Med 74:296-304
Laudenslager, Mark L; Jorgensen, Matthew J; Fairbanks, Lynn A (2012) Developmental patterns of hair cortisol in male and female nonhuman primates: lower hair cortisol levels in vervet males emerge at puberty. Psychoneuroendocrinology 37:1736-9
Fairbanks, Lynn A; Jorgensen, Matthew J; Bailey, Julia N et al. (2011) Heritability and genetic correlation of hair cortisol in vervet monkeys in low and higher stress environments. Psychoneuroendocrinology 36:1201-8
Lyn, Heidi; Pierre, Peter; Bennett, Allyson J et al. (2011) Planum temporale grey matter asymmetries in chimpanzees (Pan troglodytes), vervet (Chlorocebus aethiops sabaeus), rhesus (Macaca mulatta) and bonnet (Macaca radiata) monkeys. Neuropsychologia 49:2004-12
Pierre, Peter J; Sequeira, Marlon K; Corcoran, Christopher A et al. (2011) Hematological and serum biochemical indices in healthy bonnet macaques (Macaca radiata). J Med Primatol 40:287-93

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