Perhaps the best predictor of ethanol abuse in adolescence and young adult humans is prior fetal exposure to the drug. Yet, there is a relative paucity of evidence regarding the factors contributing to these long-term ingestive consequences. Studies have demonstrated that olfactory experience influences behavioral and neural sensory function; that postnatal behaviors controlled by odor stimuli are influence d by intrauterine experiences; and these experiences can be retained into adulthood, modulating intake and preference patterns. Taken together, these observations support the innovative central hypothesis of this proposal, that what the fetus learns from ethanol contamination of the prenatal environment is facilitated by a behavioral and neurophysiologic """"""""tuning"""""""" of the olfactory system that contribute s to the later risk for preference and abuse. In support of this proposition, we provide compelling preliminary evidence that: (1) clinically relevant in utero exposure to ethanol focuses the neurophysiologic response of the olfactory system to ethanol odor at some expense to the generally broad responsivity of the system; (2) the effect was evident in the early postnatal anima l and that it persisted into adulthood; and (3) the observed neurophysiologic """"""""tuning"""""""" to ethanol was associated wit h an alteration in the behavioral response to ethanol odor in both age groups. Thus, the long-range goal associated wit h this research program is to analyze fetal experience with ethanol in terms of its affect on an organism' s later chemosensory perception and odor-guided response to ethanol ; and to understand the mechanism s underlying the neural and behavioral effects in olfactory function related to altered odor-guided recognition and acceptance patterns of thi s drug. Guide d by our strong preliminary data, the objective of this particular application is to apply a set of interdisciplinary technique s (i.e., behavioral, neurophysiologic and anatomical) to test two specific aims: (1) we will test the hypothesis that prenatal ethanol exposure results in an altered odor-guided and drug-seeking behavioral responsiveness to ethanol that is mediated by an enhanced neurophysiologic response of the olfactory epithelium to this odorant, in both early postnatal and adult animals; and (2) we will test the hypothesis that enhanced or """"""""tuned"""""""" olfactory bulb activation to ethanol odor and changes in specific bulbar structures mediate the experience-based alterations of the response of the olfactory periphery . The proposed research is significant, because it is expected to advance and expand our understanding of the factors contributing to the initiation of ethanol intake. An understanding of these processes will facilitate the development and testing of preventive and therapeutic strategies. It will also establish a chemosensory related conceptual framework of fetal exposure with broad based importance in child development and drug abuse.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
1R01AA014871-01A2
Application #
6968718
Study Section
Neurotoxicology and Alcohol Study Section (NAL)
Program Officer
Sorensen, Roger
Project Start
2005-08-01
Project End
2010-07-31
Budget Start
2005-08-01
Budget End
2006-07-31
Support Year
1
Fiscal Year
2005
Total Cost
$342,000
Indirect Cost
Name
Upstate Medical University
Department
Other Basic Sciences
Type
Schools of Medicine
DUNS #
058889106
City
Syracuse
State
NY
Country
United States
Zip Code
13210
Eade, Amber M; Youngentob, Lisa M; Youngentob, Steven L (2016) The Interaction of Ethanol Ingestion and Social Interaction with an Intoxicated Peer on the Odor-Mediated Response to the Drug in Adolescent Rats. Alcohol Clin Exp Res 40:734-42
Mantella, Nicole M; Youngentob, Steven L (2014) Prenatal alcohol exposure increases postnatal acceptability of nicotine odor and taste in adolescent rats. PLoS One 9:e102255
Glendinning, John I; Simons, Yael M; Youngentob, Lisa et al. (2012) Fetal ethanol exposure attenuates aversive oral effects of TrpV1, but not TrpA1 agonists in rats. Exp Biol Med (Maywood) 237:236-40
Youngentob, Steven L; Kent, Paul F; Youngentob, Lisa M (2012) Gestational naltrexone ameliorates fetal ethanol exposures enhancing effect on the postnatal behavioral and neural response to ethanol. Exp Biol Med (Maywood) 237:1197-208
Berger, David F; Lombardo, John P; Peck, Joshua A et al. (2010) The effects of strain and prenatal nicotine exposure on ethanol consumption by adolescent male and female rats. Behav Brain Res 210:147-54
Eade, Amber M; Sheehe, Paul R; Youngentob, Steven L (2010) Ontogeny of the enhanced fetal-ethanol-induced behavioral and neurophysiologic olfactory response to ethanol odor. Alcohol Clin Exp Res 34:206-13
Eade, Amber M; Youngentob, Steven L (2010) The interaction of gestational and postnatal ethanol experience on the adolescent and adult odor-mediated responses to ethanol in observer and demonstrator rats. Alcohol Clin Exp Res 34:1705-13
Eade, Amber M; Sheehe, Paul R; Molina, Juan C et al. (2009) The consequence of fetal ethanol exposure and adolescent odor re-exposure on the response to ethanol odor in adolescent and adult rats. Behav Brain Funct 5:3
Homma, R; Cohen, L B; Kosmidis, E K et al. (2009) Perceptual stability during dramatic changes in olfactory bulb activation maps and dramatic declines in activation amplitudes. Eur J Neurosci 29:1027-34
Youngentob, Steven L; Glendinning, John I (2009) Fetal ethanol exposure increases ethanol intake by making it smell and taste better. Proc Natl Acad Sci U S A 106:5359-64

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