This revised R01 renewal application is in response to the Program Announcement PAR-14-338, entitled Secondary Analysis of Existing Alcohol Epidemiology Data. The overall goals for this application are to assess patterns of alcohol involvement with comorbid non-alcohol substance use symptoms and disorders, specifically assessing transition patterns for these comorbid conditions, and for subgroups of the population. Although prior population-based and clinical studies have provided strong evidence for the comorbid occurrence of alcohol abuse and dependence with other substance use disorders, there has been relatively little assessment of patterns of comorbidity as users transition through different stages of involvement with alcohol and other substances. In prior decades, alcohol and tobacco were considered 'gateways', early antecedents to illegal substance use. However, recent surveillance trends indicate reduction in tobacco use, whereas marijuana use has risen, and non-medical use of prescription medications has taken a large upswing. Alcohol consumption in the past decade has also increased among adults. Given the changing attitudes and loosening of marijuana restrictions in the recent past in some areas of the US as well as greater apparent accessibility to non-medical use of prescription medications, there is a need to improve our understanding of patterns of alcohol and other drug use comorbidity. For this project renewal, we aim to assess the comorbid patterns involving alcohol and non-alcohol substances (nicotine, non-medical prescription opiod use, non- medical prescription stimulant use, and marijuana). Specifically we aim to 1) assess secular trends in alcohol comorbidity over the past 20 year period using data from the National Longitudinal Alcohol Epidemiologic Survey (NLAES) (1991-2), the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) wave 1 (2001-2), and the NESARC III (2012-3). We also aim 2) to further evaluate potential changes over time by assessing comorbid patterns of alcohol and drug involvement prospectively with latent class (LCA) and latent transition analysis (LTA) using the 3-year prospective data from the NESARC waves 1 and 2, and the National Comorbidity Survey (NCS) and its 10-year follow-up. 3) Based on concepts in problem behavior theory, we will also assess potential predictors of progression through stages of alcohol and drug involvement, as well as protective factors and those associated with recovery from more severe stages of comorbid alcohol and drug use. Our proposed analyses will examine comorbid patterns by sex, race-ethnicity and for the adolescence/young adulthood subgroups. 4) We aim to incorporate advanced statistical strategies in our analyses, and use propensity score methods with LTA models to improve our ability to draw causal inferences from the observational data. Alcohol and other drug use comorbidity is highly prevalent, and findings from the proposed project analyses should increase our understanding of these important comorbid associations and improve our ability to identify potential targets for prevention and early intervention.

Public Health Relevance

Symptoms and disorders that co-occur with alcohol abuse and dependence are very common, in fact most individuals with alcohol use disorders have a co-occurring mental health or substance use problem at some time in their lives; because of recent changes in policies regarding marijuana use, as well as large increases in the non-medical use of prescriptions painkillers and stimulants, the relationships with drinking behaviors may also be changing. Alcohol may be increasing the transition to using illegal drugs, or the reverse may be possible; we propose to use existing data to assess trends in associations of alcohol and other drug use, as well as and to assess these patterns prospectively. The proposed analyses will help us understand these highly prevalent co-occurring conditions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
2R01AA016346-05A1
Application #
9105856
Study Section
Behavioral Genetics and Epidemiology Study Section (BGES)
Program Officer
Ruffin, Beverly
Project Start
2006-07-01
Project End
2020-07-31
Budget Start
2016-08-01
Budget End
2017-07-31
Support Year
5
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Krawczyk, Noa; Feder, Kenneth A; Saloner, Brendan et al. (2017) The association of psychiatric comorbidity with treatment completion among clients admitted to substance use treatment programs in a U.S. national sample. Drug Alcohol Depend 175:157-163
Sung, Yoon-kyu; La Flair, Lareina N; Mojtabai, Ramin et al. (2016) The Association of Alcohol Use Disorders with Suicidal Ideation and Suicide Attempts in a Population-Based Sample with Mood Symptoms. Arch Suicide Res 20:219-32
Sareen, Jitender; Wang, Yunqiao; Mota, Natalie et al. (2016) Baseline Insurance Status and Risk of Common Mental Disorders: A Propensity-Based Analysis of a Longitudinal U.S. Sample. Psychiatr Serv 67:62-70
Schuler, Megan S; Puttaiah, Savitha; Mojtabai, Ramin et al. (2015) Perceived Barriers to Treatment for Alcohol Problems: A Latent Class Analysis. Psychiatr Serv 66:1221-8
Crum, Rosa M; Mojtabai, Ramin; Sareen, Jitender (2014) Does self-medication predict the persistence or rather the recurrence of alcohol dependence?--reply. JAMA Psychiatry 71:205-6
Alvanzo, Anika A H; Storr, Carla L; Mojtabai, Ramin et al. (2014) Gender and race/ethnicity differences for initiation of alcohol-related service use among persons with alcohol dependence. Drug Alcohol Depend 140:48-55
Kaufmann, Christopher N; Chen, Lian-Yu; Crum, Rosa M et al. (2014) Treatment seeking and barriers to treatment for alcohol use in persons with alcohol use disorders and comorbid mood or anxiety disorders. Soc Psychiatry Psychiatr Epidemiol 49:1489-99
Mojtabai, Ramin; Chen, Lian-Yu; Kaufmann, Christopher N et al. (2014) Comparing barriers to mental health treatment and substance use disorder treatment among individuals with comorbid major depression and substance use disorders. J Subst Abuse Treat 46:268-73
La Flair, Lareina N; Reboussin, Beth A; Storr, Carla L et al. (2013) Childhood abuse and neglect and transitions in stages of alcohol involvement among women: a latent transition analysis approach. Drug Alcohol Depend 132:491-8
Mojtabai, Ramin; Crum, Rosa M (2013) Perceived unmet need for alcohol and drug use treatments and future use of services: results from a longitudinal study. Drug Alcohol Depend 127:59-64

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