Adolescents, especially college students, are at high risk for problem drinking, but the resulting long term consequences on brain development and function are not well studied. In this 5-year proposal, the investigators will recruit a total of 2000 18-21 year old first-year students (50% male) from 2 demographically distinct local colleges in CT;Central Connecticut State University and Trinity College. All students will be characterized at baseline at their respective campuses on a comprehensive battery of cognitive tasks, some assessing risk for problem drinking in the context of an integrative risk model and others previously identified as being sensitive to effects of alcohol abuse in adolescents. All participants will also be assessed on instruments measuring amount and patterns of current and past alcohol and drug use, consequences of use (eg mood alteration, DWI), and family history of substance use. Academic grades and SAT/ACT scores will be recorded. The sample will be stratified by alcohol use patterns and a total of 300 representative members derived from use quartiles (over-represented from the heaviest quartile, especially binge-pattern users) will undergo additional detailed assessment at the Olin Neuropsychiatry Research Center on 4 functional MRI (fMRI) paradigms assessing a. hippocampal integrity (a virtual maze spatial memory task), b. working memory circuitry (a modified Sternberg paradigm), c. reward anticipation (a monetary incentive delay task) and d. ability to inhibit a pre-potent stimulus (a Go/No-Go task), plus structural MRI and urine toxicology testing. Monthly, all participants will complete web-based ratings of alcohol and drug use amounts and patterns, mood, life events, stress and adverse consequences of use. Two years post initial testing, all available participants (~90%) will repeat the initial cognitive test battery (using alternate test forms) and detailed substance use measures. Of the 300 initial fMRI participants, the ~85% available and willing will repeat the imaging paradigms. The 3 overarching aims are to identify initial predictors of persisting alcohol and drug abuse, to detect early evidence of alcohol and drug-related impairment of brain function &cognitive problems and to determine whether particular patterns of drinking, especially binging, are most associated with cognitive decline over the 2 yrs of assessment. As part of the project we will test a theoretical model of how brain structure and function explain key relationships between risk and alcohol/substance use outcome, incorporating highly novel measures using data fusion, in order to better accomplish the overall goals. The PI and his collaborators have extensive experience with the tasks and procedures used in this Project, including web-based tracking of alcohol use.
US college students are at high risk for problem drinking. This project will recruit and test cognitively 2000 first-year students from local colleges in Connecticut, fMRI scan a representative sub-sample and assess alcohol and drug use by web-based reporting over 2 years, when all students will be retested/rescanned. Findings from this study will provide important insights on risk factors for problem drinking and how alcohol use impacts the developing adolescent brain.
|Dager, Alecia D; Tice, Madelynn R; Book, Gregory A et al. (2018) Relationship between fMRI response during a nonverbal memory task and marijuana use in college students. Drug Alcohol Depend 188:71-78|
|Ellingson, Jarrod M; Potenza, Marc N; Pearlson, Godfrey D (2018) Methodological factors as a potential source of discordance between self-report and behavioral measures of impulsivity and related constructs. Addict Behav 84:126-130|
|Meda, Shashwath A; Hawkins, Keith A; Dager, Alecia D et al. (2018) Longitudinal Effects of Alcohol Consumption on the Hippocampus and Parahippocampus in College Students. Biol Psychiatry Cogn Neurosci Neuroimaging 3:610-617|
|Zamroziewicz, Marta; Raskin, Sarah A; Tennen, Howard et al. (2017) Effects of drinking patterns on prospective memory performance in college students. Neuropsychology 31:191-199|
|Meda, Shashwath A; Dager, Alecia D; Hawkins, Keith A et al. (2017) Heavy Drinking in College Students Is Associated with Accelerated Gray Matter Volumetric Decline over a 2 Year Period. Front Behav Neurosci 11:176|
|Polimanti, Renato; Wang, Qian; Meda, Shashwath A et al. (2017) The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene. Neuropsychopharmacology 42:598-605|
|Pearlson, Godfrey David (2017) Applications of Resting State Functional MR Imaging to Neuropsychiatric Diseases. Neuroimaging Clin N Am 27:709-723|
|Meda, Shashwath A; Gueorguieva, Ralitza V; Pittman, Brian et al. (2017) Longitudinal influence of alcohol and marijuana use on academic performance in college students. PLoS One 12:e0172213|
|Polimanti, Renato; Meda, Shashwath A; Pearlson, Godfrey D et al. (2017) S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours. J Psychiatry Neurosci 42:252-261|
|Worhunsky, Patrick D; Dager, Alecia D; Meda, Shashwath A et al. (2016) A Preliminary Prospective Study of an Escalation in 'Maximum Daily Drinks', Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers. Neuropsychopharmacology 41:1637-47|
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