Alcohol abuse and dependence disorders are common in the general population, with conservative estimates suggesting that almost 1 in 5 Americans will develop an alcohol use disorder (AUD) during their lifetime. The public heath concerns associated with AUDs have been well-documented;nonetheless, important gaps in knowledge remain concerning the development and course of AUDs in the general population. To address these gaps, the proposed research will describe several important features associated with the natural course of AUDs. These include the diversity of AUD-related developmental trajectories, as well as the timing and sequencing of relationships that AUD trajectories share with common co-occurring conditions, such as cannabis use disorders, hard drug use disorders, and antisocial behavior disorders. The proposed research will also report data on the probability of relapse following the first AUD episode and the time to disorder recurrence for those with a second AUD episode. A model will also be tested for understanding the short- and longer-term outcomes of AUDs that, in turn, have implications for relapse-related processes following periods of sustained recovery. To accomplish these research aims, an existing data set from the Oregon Adolescent Depression Project (OADP) will be analyzed. The OADP is a community-based and multi-generational longitudinal study that spans the peak period for the emergence of sustained patterns of hazardous alcohol use, from adolescence through early adulthood. The research described in this proposal will address several issues not previously addressed in prior OADP publications. Four broad areas are emphasized that integrate OADP's longitudinal and developmental features. (1) Hazard functions that describe trends associated with the age of first onset for AUDs will be derived, and data will be reported on the time to recovery, the probability of relapse, and the time to disorder recurrence. (2) Subgroups of persons will be identified based on the developmental course of AUDs over the lifetime, and childhood risk factors and adult psychosocial outcomes associated with distinct trajectory subgroups will be reported. (3) The possible unidirectional and reciprocal relationships that AUDs share with other related disorders will be evaluated and documented. (4) Depressive disorders will be evaluated as possible """"""""scars"""""""" following initial AUDs that, in turn, predict the likelihood of future relapse. Findings from this proposed research have the potential to inform theories of the epidemiology of AUDs, aid the development of screening tools to identify youth who are at risk for future AUDs, facilitate the development of targeted prevention programs and therapeutic interventions, and reduce the likelihood of relapse once beneficial behavior change has occurred.

Public Health Relevance

The proposed research is consistent with two broad objectives of NIAAA's Strategic Plan for Research. (1) To increase knowledge of when problematic drinking is likely to occur, the proposed research will document the natural course and developmental trajectories of alcohol use disorders (AUDs) from childhood through age 29. (2) To increase knowledge of why some people develop AUDs and others have difficulty recovering fully from initial AUD episodes, the proposed research will examine developmental trajectories that AUDs share with related disorders as well as processes that predict relapse following periods of sustained remission.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Project (R01)
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Risk, Prevention and Intervention for Addictions Study Section (RPIA)
Program Officer
Ruffin, Beverly
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Oregon Research Institute
United States
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Farmer, Richard F; Gau, Jeff M; Seeley, John R et al. (2016) Internalizing and externalizing disorders as predictors of alcohol use disorder onset during three developmental periods. Drug Alcohol Depend 164:38-46
Duncan, Susan C; Gau, Jeff M; Farmer, Richard F et al. (2015) Comorbidity and temporal relations of alcohol and cannabis use disorders from youth through adulthood. Drug Alcohol Depend 149:80-6
Gorka, Stephanie M; Shankman, Stewart A; Olino, Thomas M et al. (2014) Anxiety disorders and risk for alcohol use disorders: the moderating effect of parental support. Drug Alcohol Depend 140:191-7
Brière, Frédéric N; Rohde, Paul; Seeley, John R et al. (2014) Comorbidity between major depression and alcohol use disorder from adolescence to adulthood. Compr Psychiatry 55:526-33