As detailed in PA-11-047 (Women and sex/gender differences in drug and alcohol abuse/dependence), gender differences in the etiology, progression, and consequences of substance use disorders (SUDs) remain incompletely understood. The current proposal focuses on one important aspect of this gap;consequences. More specifically, it is directed to clarifying how men and women may differentially experience the neurobehavioral consequences of alcohol dependence. It is noteworthy that most research directed to neurobehavioral assessments has focused on traditionally defined neurocognitive/ neuropsychological domains. Another compromised component of neurobehavior and a key aspect of successful adaptation, emotional processing, has been examined primarily in a separate literature. To better understand the breadth of neurobehavioral compromise, concurrently assessing neurocognitive and emotional performance in men and women is required. Furthermore, although studies of community samples typically reveal a female advantage on these tasks, gender differences among alcoholics are infrequently addressed. To enhance interpretation and direct future research, it is imperative that this work be conceptually driven. In response to these issues, we propose to assess cognitive and emotional functions in sufficient samples of male and female detoxified alcoholics (n=100, 50 females) and community controls (n=100, 50 females) to address both main and interaction effects. Guiding this work is a conceptual model which directs testable hypotheses, thereby informing future research and providing clinically relevant information concerning the processes underlying alcohol-related neurobehavioral (i.e., cognitive and emotional) impairment.

Public Health Relevance

The effects of alcoholism among women remain understudied. This project addresses this gap in knowledge by comparing treatment-seeking men and women and community controls in both cognitive and emotional processing. The proposed work is guided by a conceptual framework which will enhance the theoretical and clinical relevance of the study.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Research Project (R01)
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Study Section
Special Emphasis Panel (ZRG1)
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Witt, Ellen
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University of Florida
Schools of Medicine
United States
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Boissoneault, Jeff; Lewis, Ben; Nixon, Sara Jo (2018) Characterizing chronic pain and alcohol use trajectory among treatment-seeking alcoholics. Alcohol 75:47-54
Domenico, Lisa H; Lewis, Ben; Hazarika, Mythili et al. (2018) Characterizing Anxiety Among Individuals Receiving Treatment for Alcohol and Substance Use Disorders. J Am Psychiatr Nurses Assoc 24:343-351
Lewis, Ben; Hoffman, Lauren; Garcia, Christian C et al. (2018) Race and socioeconomic status in substance use progression and treatment entry. J Ethn Subst Abuse 17:150-166
Hoffman, Lauren A; Lewis, Ben; Nixon, Sara Jo (2017) Opioid Misuse Trends in Treatment Seeking Populations: Revised Prescription Opioid Policy and Temporally Corresponding Changes. Subst Use Misuse 52:1850-1858
Squeglia, Lindsay M; Boissoneault, Jeff; Van Skike, Candice E et al. (2014) Age-related effects of alcohol from adolescent, adult, and aged populations using human and animal models. Alcohol Clin Exp Res 38:2509-16