The-long term objectives of this research program are to identify those factors that cause or are associated with the decline in sexual activity that accompanies old age. Our research is focused on the decline in sexual behavior and accompanying changes in the hormonal milieu of aging rhesus macaques for what that research may contribute to an understanding of the decline in sexual behavior of aging primates, including man. In a society whose population is steadily growing older, the need for such research grows in importance. Our research is experimental, interdisciplinary, and includes the quantitative assessment of behavioral endpoints following manipulation of environmental, and hormonal variables.
Our specific aims are to determine: (1) the extent to which manipulation of environmental conditions such as the social situation and sexual partner can modify sexual performance in old males and hence permit us to assess the degree to which the decline in sexual performance is dependent upon psychological variables (2) the extent to which the decline in sexual performance is related to the competency of the brain- pituitary-gonadal system in old males as that system governs the hormonal environment modulating sexual performance and reproductive function (3) the specific changes in sexual behavior that occur over time with associated changes in serum hormone levels, and if and at what level sexual behavior reaches an asymptote in very old age. Old rhesus males (18-28 years old) whose sexual performance and hormone levels we have monitored since 1970 provide us with a unique opportunity to determine the physiological and psychological correlates of sexual behavior in an aging population of nonhuman primates.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG001608-11
Application #
3114240
Study Section
Biopsychology Study Section (BPO)
Project Start
1979-07-01
Project End
1991-01-31
Budget Start
1989-08-01
Budget End
1991-01-31
Support Year
11
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Oregon Regional Primate Research Center
Department
Type
DUNS #
City
Beaverton
State
OR
Country
United States
Zip Code
97006
Chambers, K C; Phoenix, C H (1992) Sexual behavior and serum levels of prolactin, testosterone, and estradiol in young and old rhesus males. Physiol Behav 52:13-6
Phoenix, C H; Chambers, K C (1990) Sexual performance of old and young male rhesus macaques following treatment with GnRH. Physiol Behav 47:513-7
Phoenix, C H; Walther, A M; Jensen, J N et al. (1989) The effect of human chorionic gonadotropin on serum levels of testosterone, estradiol, and sexual behavior in young and old rhesus males. Physiol Behav 46:647-53
Phoenix, C H; Jensen, J N; Chambers, K C (1989) Change of female partner and postejaculatory performance of young and old rhesus males. Physiol Behav 45:367-71
Chambers, K C; Phoenix, C H (1989) Apomorphine, deprenyl, and yohimbine fail to increase sexual behavior in rhesus males. Behav Neurosci 103:816-23
Phoenix, C H; Chambers, K C (1988) Testosterone therapy in young and old rhesus males that display low levels of sexual activity. Physiol Behav 43:479-84
Phoenix, C H; Chambers, K C (1988) Old age and sexual exhaustion in male rhesus macaques. Physiol Behav 44:157-63
Chambers, K C; Phoenix, C H (1987) Differences among ovariectomized female rhesus macaques in the display of sexual behavior without and with estradiol treatment. Behav Neurosci 101:303-8
Phoenix, C H; Jensen, J N; Chambers, K C (1986) Stimulus qualities of a preferred female partner and sexual behavior of old rhesus males. Physiol Behav 38:673-6
Chambers, K C; Phoenix, C H (1986) Testosterone is more effective than dihydrotestosterone plus estradiol in activating sexual behavior in old male rats. Neurobiol Aging 7:127-32

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