The purpose of this project is to continue studies which are allowing us to obtain a better understanding of the effects of hypertension on WAIS and neuropsychological test measures with advancing age. Continuation of our ongoing longitudinal studies will allow us to: 1) follow subjects, already tested three times, for an additional five years (Time 4 testing); 2) perform Time 3 testing and complete Time 2 testing for subjects tested initially during the 1981-1984 grant period; 3) perform Time 2 testing for subjects tested initially during the current grant period (1985- 1989); 4) expand the number of subjects in our overall cross- sectional design so that we obtain the statistical power necessary for examinations of the influence of plasma renin activity, antihypertensive medications, age at initial testing, subtypes of hypertension (e.g., complications, secondary, orthostatic, isolated systolic), and blood pressure levels, on performance. Continued collection of cross-sectional data will also allow further tests of blood pressure by age interactions for even older groups of hypertensives and normotensives. One universal failing of most studies in this area is inadequate numbers of subjects, a failure that can only be remedied by persistent and continuous collection of data under controlled conditions. Although the examination of age changes and age differences in performance for uncomplicated essential hypertensives continues to be of major importance, an increased emphasis is also being placed upon types of hypertension which involve higher risk of morbidity and mortality. Questions regarding the clinical significance of findings as well as statistical significance are raised.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
2R01AG003055-08
Application #
3114610
Study Section
Human Development and Aging Subcommittee 1 (HUD)
Project Start
1981-08-01
Project End
1990-06-30
Budget Start
1989-04-21
Budget End
1990-06-30
Support Year
8
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Maine
Department
Type
Schools of Arts and Sciences
DUNS #
City
Orono
State
ME
Country
United States
Zip Code
04473
Crichton, Georgina E; Elias, Merrill F; Alkerwi, Ala'a (2016) Chocolate intake is associated with better cognitive function: The Maine-Syracuse Longitudinal Study. Appetite 100:126-32
Elias, M F; Crichton, G E; Abhayaratna, W P (2015) Interactions between plasma homocysteine and arterial stiffness in chronic kidney disease in community-dwelling individuals: The Maine-Syracuse Study. J Hum Hypertens 29:726-31
Crichton, Georgina; Elias, Merrill; Alkerwi, Ala'a et al. (2015) Intake of Lutein-Rich Vegetables Is Associated with Higher Levels of Physical Activity. Nutrients 7:8058-71
Crichton, Georgina; Alkerwi, Ala'a; Elias, Merrrill (2015) Diet Soft Drink Consumption is Associated with the Metabolic Syndrome: A Two Sample Comparison. Nutrients 7:3569-86
Elias, Merrill F; Davey, Adam; Dore, Gregory A et al. (2014) Deterioration in renal function is associated with increased arterial stiffness. Am J Hypertens 27:207-14
Crichton, Georgina E; Elias, Merrill F; Davey, Adam et al. (2014) Cardiovascular health and cognitive function: the Maine-Syracuse Longitudinal Study. PLoS One 9:e89317
Crichton, Georgina E; Elias, Merrill F; Davey, Adam et al. (2014) Higher HDL cholesterol is associated with better cognitive function: the Maine-Syracuse study. J Int Neuropsychol Soc 20:961-70
Crichton, Georgina E; Elias, Merrill F; Dore, Gregory A et al. (2014) Measurement-to-measurement blood pressure variability is related to cognitive performance: the Maine Syracuse study. Hypertension 64:1094-101
Crichton, Georgina E; Elias, Merrill F; Davey, Adam et al. (2014) Cardiovascular health: a cross-national comparison between the Maine Syracuse Study (Central New York, USA) and ORISCAV-LUX (Luxembourg). BMC Public Health 14:253
Crichton, G E; Elias, M F; Robbins, M A (2014) Cardiovascular health and arterial stiffness: the Maine-Syracuse Longitudinal Study. J Hum Hypertens 28:444-9

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