This is a proposal to continue the study of health and functioning in middle-aged and elderly women with breast cancer, compared to women of the same age without the disease. Preliminary research suggests that the functional status of cases aged 55 to 64 is significantly poorer 3 months after diagnosis than the functional status of women of the same age without the disease. In contrast, there is little difference between cases and controls aged 75 to 84. Research is proposed to both confirm and more closely analyze these case-control differences by increasing the number of cases and controls aged 75 to 84, and introducing a younger group of women aged 40 to 54. Case-control differences will be examined in greater detail by age, with a primary focus on differences will be examined in greater detail by age, with a primary focus on differences in occupational functioning among cases and controls aged 40 to 54. A total of 276 women aged 40 to 54 and 134 aged 75 to 84, newly diagnosed with invasive breast cancer in the Detroit Metropolitan area, will be identified and interviewed at 3 and 12 months after diagnosis. A total of 410 population-based controls of the same age also will be enrolled and interviewed twice over the same period. Biomedical and treatment data for breast cancer cases will obtained from the population-based Metropolitan Detroit Cancer Surveillance System (MDCSS) operated by the Division of Epidemiology, Michigan Cancer Foundation. Interview, biomedical, and treatment data will be combined with those data already collected in the initial study of cases and controls aged 55 to 84. Multivariate techniques will be employed to assess differences in physical and social functioning, occupational status and performance, and economic resources. This research is designed to provide an assessment of functional needs, occupational performance, and economic resources, which may suggest, in turn, rehabilitation and home-care programs for those middle-aged and elderly women with breast cancer in greatest need.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG004969-06
Application #
3115500
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1984-07-01
Project End
1990-09-30
Budget Start
1989-07-01
Budget End
1990-09-30
Support Year
6
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Barbara Ann Karmanos Cancer Institute
Department
Type
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48201
Izano, Monika; Satariano, William A; Hiatt, Robert A et al. (2015) Smoking and mortality after breast cancer diagnosis: the health and functioning in women study. Cancer Med 4:315-24
Izano, Monika; Satariano, William A; Tammemagi, Martin C et al. (2014) Long-term outcomes among African-American and white women with breast cancer: what is the impact of comorbidity? J Geriatr Oncol 5:266-75
Vaeth, P A; Satariano, W A; Ragland, D R (2000) Limiting comorbid conditions and breast cancer stage at diagnosis. J Gerontol A Biol Sci Med Sci 55:M593-600
Vaeth, P A; Satariano, W A (1998) Alcohol consumption and breast cancer stage at diagnosis. Alcohol Clin Exp Res 22:928-34
Satariano, W A; Ragland, D R (1996) Upper-body strength and breast cancer: a comparison of the effects of age and disease. J Gerontol A Biol Sci Med Sci 51:M215-9
Satariano, W A; Ragland, D R; DeLorenze, G N (1996) Limitations in upper-body strength associated with breast cancer: a comparison of black and white women. J Clin Epidemiol 49:535-44
Satariano, W A; DeLorenze, G N (1996) The likelihood of returning to work after breast cancer. Public Health Rep 111:236-41
Satariano, W A; Ragland, D R (1994) The effect of comorbidity on 3-year survival of women with primary breast cancer. Ann Intern Med 120:104-10
Satariano, W A (1993) Aging, comorbidity, and breast cancer survival: an epidemiologic view. Adv Exp Med Biol 330:1-11
Moritz, D J; Satariano, W A (1993) Factors predicting stage of breast cancer at diagnosis in middle aged and elderly women: the role of living arrangements. J Clin Epidemiol 46:443-54

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