Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
3R01AG004984-08A1S1
Application #
2048939
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1989-09-30
Project End
1997-08-31
Budget Start
1995-06-15
Budget End
1995-08-31
Support Year
8
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Oklahoma Health Sciences Center
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
937727907
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117
Yamano, T; Kosanke, S D; Rikans, L E (1999) Attenuation of cadmium-induced liver injury in senescent male fischer 344 rats: role of metallothionein and glutathione. Toxicol Appl Pharmacol 161:225-30
Rikans, L E; DeCicco, L A; Hornbrook, K R et al. (1999) Effect of age and carbon tetrachloride on cytokine concentrations in rat liver. Mech Ageing Dev 108:173-82
DeCicco, L A; Rikans, L E; Tutor, C G et al. (1998) Serum and liver concentrations of tumor necrosis factor alpha and interleukin-1beta following administration of carbon tetrachloride to male rats. Toxicol Lett 98:115-21
Rikans, L E; Hornbrook, K R (1998) Thiol-disulfide exchange systems in the liver of aging Fischer 344 rats. Gerontology 44:72-7
Rikans, L E; Hornbrook, K R (1997) Lipid peroxidation, antioxidant protection and aging. Biochim Biophys Acta 1362:116-27
Rikans, L E; Ardinska, V; Hornbrook, K R (1997) Age-associated increase in ferritin content of male rat liver: implication for diquat-mediated oxidative injury. Arch Biochem Biophys 344:85-93
Rikans, L E; Lopez, T R; Hornbrook, K R (1996) Age and gender differences in hepatic ascorbic acid concentrations and NADPH-dehydroascorbic acid reductase activity. Mech Ageing Dev 91:165-9
Rikans, L E; Hornbrook, K R; Cai, Y (1994) Carbon tetrachloride hepatotoxicity as a function of age in female Fischer 344 rats. Mech Ageing Dev 76:89-99
Rikans, L E; Cai, Y; Kosanke, S D et al. (1993) Redox cycling and hepatotoxicity of diquat in aging male Fischer 344 rats. Drug Metab Dispos 21:605-10
Hornbrook, K R; Kosanke, S D; Rikans, L E (1993) Aged mice are resistant to the hepatotoxic effects of endotoxin and galactosamine. Exp Mol Pathol 59:27-37

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