The purpose of this project is to investigate, by nuclear magnetic resonance, phospholipid and energy metabolism in rat and human brain as a function of normal aging, as well as in human Alzheimer's disease, and in a rat central hypocholinergic model of Alzheimer's disease. These studies are designed to determine what, if any, brain metabolic changes are seen with normal aging, whether similar or different metabolic changes are seen in Alzheimer's disease and in a rat model of Alzheimer's disease; and whether a new class of drugs known as nootropic drugs or cognition activators can favorably alter abnormal brain metabolism.
| Pettegrew, J W; Moossy, J; Withers, G et al. (1988) 31P nuclear magnetic resonance study of the brain in Alzheimer's disease. J Neuropathol Exp Neurol 47:235-48 |
| Pettegrew, J W; Withers, G; Panchalingam, K et al. (1988) Considerations for brain pH assessment by 31P NMR. Magn Reson Imaging 6:135-42 |
| Pettegrew, J W; Kopp, S J; Minshew, N J et al. (1987) 31P nuclear magnetic resonance studies of phosphoglyceride metabolism in developing and degenerating brain: preliminary observations. J Neuropathol Exp Neurol 46:419-30 |
| Pettegrew, J W; Short, J W; Woessner, R D et al. (1987) The effect of lithium on the membrane molecular dynamics of normal human erythrocytes. Biol Psychiatry 22:857-71 |
| Pettegrew, J W; Withers, G; Panchalingam, K et al. (1987) 31P nuclear magnetic resonance (NMR) spectroscopy of brain in aging and Alzheimer's disease. J Neural Transm Suppl 24:261-8 |
