Abstract

The major goal of the proposed research is to elucidate the cognitive and neural bases of working memory. By testing subjects with Alzheimer's disease (AD), Parkinson's disease (PD), or discrete lesions within frontal, temporal, or parietal cortex, and comparing them with normal control subjects (NCS), the investigators hope to define the neural networks that support working memory and to dissect the functional specialization of structure within it. Working memory relies on executive functions and may be organized into at least two independent subsystem, one for storing and manipulating memory for locations in space and one for storing and manipulating memory for the features of objects. This application will administer tests of working memory and tests of non-mnemonic cognitive operations that support working memory performance. These tests will manipulate spatial location, objects, words, encoding time, decision time, movement time, and retrieval time. Converging evidence about the neural substrate for these operations will be obtained from studies on patients and from fMRI imaging.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG006605-12
Application #
2653722
Study Section
Human Development and Aging Subcommittee 3 (HUD)
Project Start
1992-03-17
Project End
2000-01-31
Budget Start
1998-02-01
Budget End
1999-01-31
Support Year
12
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Other Basic Sciences
Type
Other Domestic Higher Education
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Bohbot, Veronique D; Corkin, Suzanne (2007) Posterior parahippocampal place learning in H.M. Hippocampus 17:863-72
Steinvorth, Sarah; Levine, Brian; Corkin, Suzanne (2005) Medial temporal lobe structures are needed to re-experience remote autobiographical memories: evidence from H.M. and W.R. Neuropsychologia 43:479-96
Postle, Bradley R; Desposito, Mark; Corkin, Suzanne (2005) Effects of verbal and nonverbal interference on spatial and object visual working memory. Mem Cognit 33:203-12
Ullman, Michael T; Pancheva, Roumyana; Love, Tracy et al. (2005) Neural correlates of lexicon and grammar: evidence from the production, reading, and judgment of inflection in aphasia. Brain Lang 93:185-238; discussion 239-42
Skotko, Brian G; Kensinger, Elizabeth A; Locascio, Joseph J et al. (2004) Puzzling thoughts for H. M.: can new semantic information be anchored to old semantic memories? Neuropsychology 18:756-69
Kensinger, Elizabeth A; Shearer, Deirdre K; Locascio, Joseph J et al. (2003) Working memory in mild Alzheimer's disease and early Parkinson's disease. Neuropsychology 17:230-9
Kensinger, Elizabeth A; Brierley, Barbara; Medford, Nick et al. (2002) Effects of normal aging and Alzheimer's disease on emotional memory. Emotion 2:118-34
Xu, Y; Corkin, S (2001) H.M. revisits the Tower of Hanoi Puzzle. Neuropsychology 15:69-79
Binetti, G; Locascio, J J; Corkin, S et al. (2000) Differences between Pick disease and Alzheimer disease in clinical appearance and rate of cognitive decline. Arch Neurol 57:225-32
Postle, B R; Corkin, S (1999) Manipulation of familiarity reveals a necessary lexical component of the word-stem completion priming effect. Mem Cognit 27:12-25

Showing the most recent 10 out of 24 publications