The proposed project will continue an ongoing, normative, longitudinal study bone homeostasis in white and black women, two racial groups with differing fracture prevalence. Its purpose is to investigate the mechanisms by which black women may be protected from osteoporosis and to delineate the natural history of bone loss and its determinants in a healthy, biracial female population. While it is generally believed that black women have a lower incidence of osteoporotic fracture than whites, the reason for their apparent protection is unknown. Although undoubtedly due, in part, to a higher incidence of obesity, higher trabecular and/or cortical bone mass, independent of weight, may be a major determinant. The mechanism(s) by which higher bone mass arises in blacks has not previously been investigated. It is possible either (1) that bone mass is higher in blacks at skeletal maturity so that despite similar rates of loss, bone mass remains above the fracture threshold; or (2) that trabecular and cortical bone loss is less severe in black women. Currently available cross-sectional studies are inadequate to determine which of these possibilities apply and no previous longitudinal study has compared rates of bone loss in the white and black female populations. Better characterization of the determinants of bone mass an rates of bone loss in these groups could lead to new insights into the etiologies of osteoporosis and to the identification of prevention and treatment modalities. Utilizing single and dual photon absorptiometry to quantitate appendicular and axial bone mass and measurements of hormonal, physical and nutritional parameters known to affect bone metabolism, this study will (1) simultaneously and prospectively compared bone mass, rates of bone loss and the determinants of skeletal health in 360 white and black women to detect protective and risk factors in the two racial groups; (2) assess the natural history of bone loss pre-, peri- and postmenopausally to detect the age of onset and rates of clinically significant demineralization; and (3) determine the relationship of peak bone mass and rates of bone loss to some of the determinants of bone homeostasis, including vitamin D, parathyroid hormone, and gonadal steroid levels; activity and physical fitness; diet; and body composition, both within and between racial groups.
| Luckey, M M; Wallenstein, S; Lapinski, R et al. (1996) A prospective study of bone loss in African-American and white women--a clinical research center study. J Clin Endocrinol Metab 81:2948-56 |
| Meier, D E; Luckey, M M; Wallenstein, S et al. (1992) Racial differences in pre- and postmenopausal bone homeostasis: association with bone density. J Bone Miner Res 7:1181-9 |
| Meier, D E; Luckey, M M; Wallenstein, S et al. (1991) Calcium, vitamin D, and parathyroid hormone status in young white and black women: association with racial differences in bone mass. J Clin Endocrinol Metab 72:703-10 |
| Luckey, M M; Meier, D E; Mandeli, J P et al. (1989) Radial and vertebral bone density in white and black women: evidence for racial differences in premenopausal bone homeostasis. J Clin Endocrinol Metab 69:762-70 |
