Pathology has several critical roles in studies of aging biomarkers. It can provide morphological correlates of functional changes that occur in aging and may suggest mechanisms for functional biomarkers. Data from a particular animal can be excluded from a data set if it has a purturbing randomly occurring lesion. Lesions can also be viewed as biomarkers in themselves. This is so for lesions that occur sporadically with increasing frequency as animals age and for those that progress in severity in most of all animals. This 5 year program is designed to study all tissues in 30 animals of each of the possible groups available from the Biomarker Program of the NIA: 2 species, 6 genetypes, 2 sexes, 2 diet groups, restricted and ad libitum fed, and a full range of 6 monthly time intervals from 6 to 30 months and older if possible. As many animals as possible will be studied by other investigators before necropsy. Data for each of the kinds of lesions occurring in the animals will be evaluated and the prevalence of each lesion will be compared between the various groups. Some lesions will be semiquantitatively evaluated for severity. Data will be studied for differences between species, genotypes and sexes and most importantly between age and diet groups. Correlations between functional biomarkers and lesions will be studied. The data generated will serve to classify, characterize and define the lesions occurring in the animals used in the Biomarker Program. The data will be useful for all investigators involved in the Biomarker Program.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
1R01AG007747-01
Application #
3119021
Study Section
Aging Review Committee (AGE)
Project Start
1988-04-01
Project End
1993-03-31
Budget Start
1988-04-01
Budget End
1989-03-31
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Tufts University
Department
Type
Schools of Veterinary Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111
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Obin, M; Halbleib, M; Lipman, R et al. (2000) Calorie restriction increases light-dependent photoreceptor cell loss in the neural retina of fischer 344 rats. Neurobiol Aging 21:639-45
Lipman, R D; Dallal, G E; Bronson, R T (1999) Lesion biomarkers of aging in B6C3F1 hybrid mice. J Gerontol A Biol Sci Med Sci 54:B466-77
Lipman, R D; Dallal, G E; Bronson, R T (1999) Effects of genotype and diet on age-related lesions in ad libitum fed and calorie-restricted F344, BN, and BNF3F1 rats. J Gerontol A Biol Sci Med Sci 54:B478-91
Lipman, R D; Smith, D E; Blumberg, J B et al. (1998) Effects of caloric restriction or augmentation in adult rats: longevity and lesion biomarkers of aging. Aging (Milano) 10:463-70
Lipman, R D; Bronson, R T; Wu, D et al. (1998) Disease incidence and longevity are unaltered by dietary antioxidant supplementation initiated during middle age in C57BL/6 mice. Mech Ageing Dev 103:269-84
Lipman, R D (1997) Pathobiology of aging rodents: inbred and hybrid models. Exp Gerontol 32:215-28
Lipman, R D; Smith, D E; Bronson, R T et al. (1995) Is late-life caloric restriction beneficial? Aging (Milano) 7:136-9
Bronson, R T; Lipman, R D; Harrison, D E (1993) Age-related gliosis in the white matter of mice. Brain Res 609:124-8
Bronson, R T; Lipman, R D (1993) FRAR course on laboratory approaches to aging. The role of pathology in rodent experimental gerontology. Aging (Milano) 5:253-7

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