Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG007752-09
Application #
2049887
Study Section
Biological and Clinical Aging Review Committee (BCA)
Project Start
1988-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Physiology
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Khan, Amir S; Sane, David C; Wannenburg, Thomas et al. (2002) Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system. Cardiovasc Res 54:25-35
Wannenburg, T; Khan, A S; Sane, D C et al. (2001) Growth hormone reverses age-related cardiac myofilament dysfunction in rats. Am J Physiol Heart Circ Physiol 281:H915-22
Lynch, C D; Cooney, P T; Bennett, S A et al. (1999) Effects of moderate caloric restriction on cortical microvascular density and local cerebral blood flow in aged rats. Neurobiol Aging 20:191-200
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Sonntag, W E; Xu, X; Ingram, R L et al. (1995) Moderate caloric restriction alters the subcellular distribution of somatostatin mRNA and increases growth hormone pulse amplitude in aged animals. Neuroendocrinology 61:601-8
D'Costa, A P; Xu, X; Ingram, R L et al. (1995) Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats. Neuroscience 65:805-13
Xu, X; Bennett, S A; Ingram, R L et al. (1995) Decreases in growth hormone receptor signal transduction contribute to the decline in insulin-like growth factor I gene expression with age. Endocrinology 136:4551-7
Breese, C R; Sonntag, W E (1995) Effect of ethanol on plasma and hepatic insulin-like growth factor regulation in pregnant rats. Alcohol Clin Exp Res 19:867-73

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