Alzheimer's patients often experience rapid weight loss and deterioration in nutritional status. This has led to the suggestion that their energy expenditure is elevated relative to their body size. In this 3 yr proposal, our Major Aim is to examine whether total daily energy expenditure (TDEE), derived from doubly labeled water, and its components (resting metabolic rate and physical activity) are higher in Alzheimer's patients compared to normal elderly. We hypothesize that energy expenditure of Alzheimer's patients will not be elevated after normalizing for differences in fat-free mass. Thus, a reduced intake relative to their energy requirement will be implicated in their weight loss. The Secondary Aim of this proposal is to use the data collected to develop and cross-validate new models to predict energy requirements as derived from biological markers of TDEE in Alzheimer's patients and normal elderly and compare them to current energy recommendations. Accurate information to define suitable levels of energy intake is required for the prevention and treatment of the extremes of fatness and leanness that arise in Alzheimer's patients and healthy elderly. Current recommendations for energy requirements are based on out-dated food intake data and have not considered the influence of body composition and physical activity as important determinants of energy needs. These limitations have led to the suggestion that prescription of energy requirements should be based on the measurement of energy expenditure. We propose that energy requirements will be most accurately predicted from a marker of physical activity and fat-free mass in Alzheimer's patients and normal elderly. In combination, these experiments will use stable isotope methodology and indirect calorimetry to examine energy metabolism in Alzheimer's patients and normal elderly, and offer new guidelines to predict energy requirements based on measures of energy expenditure.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
2R01AG007857-06
Application #
3119221
Study Section
Nutrition Study Section (NTN)
Project Start
1988-08-01
Project End
1994-01-31
Budget Start
1993-08-01
Budget End
1994-01-31
Support Year
6
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Vermont & St Agric College
Department
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Arciero, P J; Gardner, A W; Benowitz, N L et al. (1998) Relationship of blood pressure, heart rate and behavioral mood state to norepinephrine kinetics in younger and older men following caffeine ingestion. Eur J Clin Nutr 52:805-12
Dvorak, R V; Calles-Escandon, J; Poehlman, E T (1998) Measurement and prediction of sympathetic nervous system activity in humans. Life Sci 62:1397-406
Dvorak, R V; Poehlman, E T (1998) Norepinephrine kinetics in older women: relationship to physical activity and blood pressure. Exp Gerontol 33:507-16
Dvorak, R V; Poehlman, E T (1998) Appendicular skeletal muscle mass, physical activity, and cognitive status in patients with Alzheimer's disease. Neurology 51:1386-90
Nicklas, B J; Toth, M J; Goldberg, A P et al. (1997) Racial differences in plasma leptin concentrations in obese postmenopausal women. J Clin Endocrinol Metab 82:315-7
Nicklas, B J; Toth, M J; Poehlman, E T (1997) Daily energy expenditure is related to plasma leptin concentrations in older African-American women but not men. Diabetes 46:1389-92
Toth, M J; Poehlman, E T (1996) Effects of exercise on daily energy expenditure. Nutr Rev 54:S140-8
Goran, M I; Allison, D B; Poehlman, E T (1995) Issues relating to normalization of body fat content in men and women. Int J Obes Relat Metab Disord 19:638-43
Gardner, A W; Poehlman, E T (1995) Predictors of the age-related increase in blood pressure in men and women. J Gerontol A Biol Sci Med Sci 50A:M1-6
Gardner, A W; Poehlman, E T (1995) Exercise rehabilitation programs for the treatment of claudication pain. A meta-analysis. JAMA 274:975-80

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