Abstract

The primary goals of this proposal are to quantify regional mu-opiate receptors and glucose metabolism in possible and probable Alzheimer's Disease and normal controls by positron emission tomography (PET) and to relate abnormalities of neuropsychological parameters in Alzheimer's Disease to PET findings. Additionally, we will determine the specificity of changes in mu-opiate receptors to Alzheimer's Disease by examining Multi Infarct Dementia patients in a similar manner. These results will 1) improve our understanding of the basic pathophysiology of Alzheimer's Disease, 2) relate parameters of cognitive decline to neurochemistry and 3) possible lead to earlier diagnosis of Alzheimer's Disease through quantification of mu-opiate receptors than possible by clinical examination or by measuring glucose metabolism.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG008740-04
Application #
3120489
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1990-04-01
Project End
1995-03-31
Budget Start
1993-04-10
Budget End
1994-03-31
Support Year
4
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Zubieta, J K; Dannals, R F; Frost, J J (1999) Gender and age influences on human brain mu-opioid receptor binding measured by PET. Am J Psychiatry 156:842-8
Smith, Y R; Zubieta, J K; del Carmen, M G et al. (1998) Brain opioid receptor measurements by positron emission tomography in normal cycling women: relationship to luteinizing hormone pulsatility and gonadal steroid hormones. J Clin Endocrinol Metab 83:4498-505
Meltzer, C C; Zubieta, J K; Links, J M et al. (1996) MR-based correction of brain PET measurements for heterogeneous gray matter radioactivity distribution. J Cereb Blood Flow Metab 16:650-8
Madar, I; Lever, J R; Kinter, C M et al. (1996) Imaging of delta opioid receptors in human brain by N1'-([11C]methyl)naltrindole and PET. Synapse 24:19-28
Meltzer, C C; Zubieta, J K; Brandt, J et al. (1996) Regional hypometabolism in Alzheimer's disease as measured by positron emission tomography after correction for effects of partial volume averaging. Neurology 47:454-61
Flesher, J E; Scheffel, U; London, E D et al. (1994) In vivo labeling of nicotinic cholinergic receptors in brain with [3H]cytisine. Life Sci 54:1883-90
Price, J C; Mayberg, H S; Dannals, R F et al. (1993) Measurement of benzodiazepine receptor number and affinity in humans using tracer kinetic modeling, positron emission tomography, and [11C]flumazenil. J Cereb Blood Flow Metab 13:656-67
Frost, J J; Rosier, A J; Reich, S G et al. (1993) Positron emission tomographic imaging of the dopamine transporter with 11C-WIN 35,428 reveals marked declines in mild Parkinson's disease. Ann Neurol 34:423-31
Frost, J J (1992) Receptor imaging by positron emission tomography and single-photon emission computed tomography. Invest Radiol 27 Suppl 2:S54-8
Muller-Gartner, H W; Links, J M; Prince, J L et al. (1992) Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects. J Cereb Blood Flow Metab 12:571-83

Showing the most recent 10 out of 11 publications