The general aim is to analyze the long-term association of sociodemographic, behavioral and biological factors with transitions from good to morbid or disabled health status, and eventually to death. These associations are studied in the Finnish, Italian and Dutch Cohorts of the Seven Countries Study that have been followed-up with repeated examinations during 30 years from middle-age (40-59 years) to old age (70-89 years). The total study population is 4755 men. Before the 25-year follow-up, the available data consists mainly of cardiovascular risk factors, including diet, results of medical examinations and mortality and morbidity follow-up. At the 25-year follow-up, mental and functional capacities were assessed in Finland and Italy. Examinations at the 30-year follow-up in all three countries include tests of mental capacity, ADL- and IADL-activities, depressive and other symptoms, social network, life satisfaction and objective measures of functional capacity, in addition to the past measurements. The analyses will be conducted both separately for the three countries and using pooled data. The following four main aims correspond also to the main responsibilities of the four countries involved in analyzing collaborative data: 1) Prevalence and determinants of mental and functional capacities at old age (Finland), 2) Diet and disability (The Netherlands), 3) Risk factors and their changes - association with mortality and morbidity (Italy), 4) Application of a multivariate stochastic process model of human ageing and a model for multivariate event history analysis of morbidity and dIsability change (Duke University, USA). The data are collected in five sites in three countries, in very different socio-economic and cultural settings, where common features in ageing and health processes across sites are more likely to be a product of basic physiological mechanisms. Together with the long follow-up with standardized methodology, this is one of the unique streghts of the proposed study.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Project (R01)
Project #
Application #
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Kuopio
Zip Code
Giltay, Erik J; Nissinen, Aulikki; Giampaoli, Simona et al. (2009) Apolipoprotein E genotype modifies the association between midlife lung function and cognitive function in old age. Dement Geriatr Cogn Disord 28:433-41
Pelkonen, Margit; Notkola, Irma-Leena; Nissinen, Aulikki et al. (2006) Thirty-year cumulative incidence of chronic bronchitis and COPD in relation to 30-year pulmonary function and 40-year mortality: a follow-up in middle-aged rural men. Chest 130:1129-37
Kalme, Tarja; Seppala, Markku; Qiao, Qing et al. (2005) Sex hormone-binding globulin and insulin-like growth factor-binding protein-1 as indicators of metabolic syndrome, cardiovascular risk, and mortality in elderly men. J Clin Endocrinol Metab 90:1550-6
Qiao, Qing; Dekker, Jacqueline M; de Vegt, Femmie et al. (2004) Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbA1c. J Clin Epidemiol 57:590-6
Pelkonen, Margit; Notkola, Irma-Leena; Lakka, Timo et al. (2003) Delaying decline in pulmonary function with physical activity: a 25-year follow-up. Am J Respir Crit Care Med 168:494-9
Houterman, S; Boshuizen, H C; Verschuren, W M M et al. (2002) Predicting cardiovascular risk in the elderly in different European countries. Eur Heart J 23:294-300
Harrela, M; Qiao, Q; Koistinen, R et al. (2002) High serum insulin-like growth factor binding protein-1 is associated with increased cardiovascular mortality in elderly men. Horm Metab Res 34:144-9
Pelkonen, M; Notkola, I L; Tukiainen, H et al. (2001) Smoking cessation, decline in pulmonary function and total mortality: a 30 year follow up study among the Finnish cohorts of the Seven Countries Study. Thorax 56:703-7
Stengard, J H; Kardia, S L; Tervahauta, M et al. (1999) Utility of the predictors of coronary heart disease mortality in a longitudinal study of elderly Finnish men aged 65 to 84 years is dependent on context defined by Apo E genotype and area of residence. Clin Genet 56:367-77
Giampaoli, S; Ferrucci, L; Cecchi, F et al. (1999) Hand-grip strength predicts incident disability in non-disabled older men. Age Ageing 28:283-8

Showing the most recent 10 out of 25 publications