Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
7R01AG009031-07
Application #
2050557
Study Section
Neurology A Study Section (NEUA)
Project Start
1990-05-01
Project End
1997-04-30
Budget Start
1995-05-01
Budget End
1997-04-30
Support Year
7
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Dentistry
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Wilson, D M; Binder, L I (1997) Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease. Am J Pathol 150:2181-95
Carmel, G; Mager, E M; Binder, L I et al. (1996) The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology. J Biol Chem 271:32789-95
Wilson, D M; Binder, L I (1995) Polymerization of microtubule-associated protein tau under near-physiological conditions. J Biol Chem 270:24306-14
Brady, R M; Zinkowski, R P; Binder, L I (1995) Presence of tau in isolated nuclei from human brain. Neurobiol Aging 16:479-86
Wang, Y; Loomis, P A; Zinkowski, R P et al. (1993) A novel tau transcript in cultured human neuroblastoma cells expressing nuclear tau. J Cell Biol 121:257-67
Greenberg, S G; Davies, P; Schein, J D et al. (1992) Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau. J Biol Chem 267:564-9