Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG009235-07
Application #
2050677
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1990-09-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Dalton, Timothy P; Chen, Ying; Schneider, Scott N et al. (2004) Genetically altered mice to evaluate glutathione homeostasis in health and disease. Free Radic Biol Med 37:1511-26
Dieter, Matthew Z; Freshwater, Sarah L; Miller, Marian L et al. (2003) Pharmacological rescue of the 14CoS/14CoS mouse: hepatocyte apoptosis is likely caused by endogenous oxidative stress. Free Radic Biol Med 35:351-67
Yang, Yi; Dieter, Matthew Z; Chen, Ying et al. (2002) Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response. J Biol Chem 277:49446-52
Solis, Willy A; Childs, Nicole L; Weedon, Michael N et al. (2002) Retrovirally expressed metal response element-binding transcription factor-1 normalizes metallothionein-1 gene expression and protects cells against zinc, but not cadmium, toxicity. Toxicol Appl Pharmacol 178:93-101
Solis, Willy A; Dalton, Timothy P; Dieter, Matthew Z et al. (2002) Glutamate-cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause oxidative stress. Biochem Pharmacol 63:1739-54
Dieter, M Z; Freshwater, S L; Solis, W A et al. (2001) Tyrphostin [correction of Tryphostin] AG879, a tyrosine kinase inhibitor: prevention of transcriptional activation of the electrophile and the aromatic hydrocarbon response elements. Biochem Pharmacol 61:215-25
Nebert, D W; Roe, A L; Dieter, M Z et al. (2000) Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis. Biochem Pharmacol 59:65-85
Dalton, T P; Solis, W A; Nebert, D W et al. (2000) Characterization of the MTF-1 transcription factor from zebrafish and trout cells. Comp Biochem Physiol B Biochem Mol Biol 126:325-35
Dalton, T P; Dieter, M Z; Yang, Y et al. (2000) Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous. Biochem Biophys Res Commun 279:324-9
Vasiliou, V; Buetler, T; Eaton, D L et al. (2000) Comparison of oxidative stress response parameters in newborn mouse liver versus simian virus 40 (SV40)-transformed hepatocyte cell lines. Biochem Pharmacol 59:703-12

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