Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG009574-05
Application #
2050901
Study Section
General Medicine B Study Section (GMB)
Project Start
1991-02-01
Project End
1997-01-31
Budget Start
1995-02-20
Budget End
1997-01-31
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Kretz-Rommel, A; Duncan, S R; Rubin, R L (1997) Autoimmunity caused by disruption of central T cell tolerance. A murine model of drug-induced lupus. J Clin Invest 99:1888-96
Jiang, X; Wu, T H; Rubin, R L (1997) Bridging of neutrophils to target cells by opsonized zymosan enhances the cytotoxicity of neutrophil-produced H2O2. J Immunol 159:2468-75
Kretz-Rommel, A; Rubin, R L (1997) A metabolite of the lupus-inducing drug procainamide prevents anergy induction in T cell clones. J Immunol 158:4465-70
Starkebaum, G; Kenyon, C M; Simrell, C R et al. (1996) Procainamide-induced agranulocytosis differs serologically and clinically from procainamide-induced lupus. Clin Immunol Immunopathol 78:112-9
Rubin, R L; Burlingame, R W; Arnott, J E et al. (1995) IgG but not other classes of anti-[(H2A-H2B)-DNA] is an early sign of procainamide-induced lupus. J Immunol 154:2483-93
Bell, S A; Du Clos, T W; Khursigara, G et al. (1995) Autoantibodies to cryptic epitopes of C-reactive protein and other acute phase proteins in the toxic oil syndrome. J Autoimmun 8:293-303
Rubin, R L (1994) Role of xenobiotic oxidative metabolism. Lupus 3:479-82
Jiang, X; Khursigara, G; Rubin, R L (1994) Transformation of lupus-inducing drugs to cytotoxic products by activated neutrophils. Science 266:810-3
Rubin, R L (1992) Autoantibody specificity in drug-induced lupus and neutrophil-mediated metabolism of lupus-inducing drugs. Clin Biochem 25:223-34
Bell, S A; Hobbs, M V; Rubin, R L (1992) Isotype-restricted hyperimmunity in a murine model of the toxic oil syndrome. J Immunol 148:3369-76