Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
2R01AG010034-05A2
Application #
2051291
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1991-08-01
Project End
1998-12-31
Budget Start
1996-01-25
Budget End
1996-12-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Physiology
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Brustovetsky, Nickolay; Dubinsky, Janet M; Antonsson, Bruno et al. (2003) Two pathways for tBID-induced cytochrome c release from rat brain mitochondria: BAK- versus BAX-dependence. J Neurochem 84:196-207
Brustovetsky, Nickolay; Brustovetsky, Tatiana; Jemmerson, Ronald et al. (2002) Calcium-induced cytochrome c release from CNS mitochondria is associated with the permeability transition and rupture of the outer membrane. J Neurochem 80:207-18
Brustovetsky, N; Brustovetsky, T; Dubinsky, J M (2001) On the mechanisms of neuroprotection by creatine and phosphocreatine. J Neurochem 76:425-34
Araki, E; Forster, C; Dubinsky, J M et al. (2001) Cyclooxygenase-2 inhibitor ns-398 protects neuronal cultures from lipopolysaccharide-induced neurotoxicity. Stroke 32:2370-5
Lakkaraju, A; Dubinsky, J M; Low, W C et al. (2001) Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes. J Biol Chem 276:32000-7
Brustovetsky, N; Dubinsky, J M (2000) Dual responses of CNS mitochondria to elevated calcium. J Neurosci 20:103-13
Brustovetsky, N; Dubinsky, J M (2000) Limitations of cyclosporin A inhibition of the permeability transition in CNS mitochondria. J Neurosci 20:8229-37
Dubinsky, J M; Brustovetsky, N; Pinelis, V et al. (1999) The mitochondrial permeability transition: the brain's point of view. Biochem Soc Symp 66:75-84
Brustovetsky, N; Dubinsky, J M (1999) EDTA-induced monovalent fluxes through the Ca2+ uniporter in brain mitochondria. Ann N Y Acad Sci 893:258-60
Dubinsky, J M; Levi, Y (1998) Calcium-induced activation of the mitochondrial permeability transition in hippocampal neurons. J Neurosci Res 53:728-41

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