Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG010252-03
Application #
2051508
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1992-09-30
Project End
1997-07-31
Budget Start
1994-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Pediatrics
Type
Other Domestic Higher Education
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Crawford, C A; Levine, M S (1997) Dopaminergic function in the neostriatum and nucleus accumbens of young and aged Fischer 344 rats. Neurobiol Aging 18:57-66
Colwell, C S; Levine, M S (1997) Histamine modulates NMDA-dependent swelling in the neostriatum. Brain Res 766:205-12
Levine, M S; Li, Z; Cepeda, C et al. (1996) Neuromodulatory actions of dopamine on synaptically-evoked neostriatal responses in slices. Synapse 24:65-78
Cromwell, H C; Levine, M S (1996) Neocortical damage alters synaptic responses of neostriatal neurons in vitro. Neuroscience 75:361-72
Cepeda, C; Li, Z; Levine, M S (1996) Aging reduces neostriatal responsiveness to N-methyl-D-aspartate and dopamine: an in vitro electrophysiological study. Neuroscience 73:733-50
Altemus, K L; Levine, M S (1996) Potassium channel blockade does not alter the modulatory effects of dopamine in neostriatal slices. Brain Res 718:212-6
Colwell, C S; Levine, M S (1996) Glutamate receptor-induced toxicity in neostriatal cells. Brain Res 724:205-12
Levine, M S; Altemus, K L; Cepeda, C et al. (1996) Modulatory actions of dopamine on NMDA receptor-mediated responses are reduced in D1A-deficient mutant mice. J Neurosci 16:5870-82
Colwell, C S; Altemus, K L; Cepeda, C et al. (1996) Regulation of N-methyl-D-aspartate-induced toxicity in the neostriatum: a role for metabotropic glutamate receptors? Proc Natl Acad Sci U S A 93:1200-4
Colwell, C S; Altemus, K L; Levine, M S (1996) Metabotropic glutamate receptor activation selectively limits excitotoxic damage in the intact neostriatum. Brain Res 726:223-6

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