Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Project (R01)
Project #
5R01AG011054-03
Application #
2052265
Study Section
Neurology A Study Section (NEUA)
Project Start
1993-03-01
Project End
1998-02-28
Budget Start
1995-03-01
Budget End
1998-02-28
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Ruben, George C; Novak, Michal; Edwards, Patricia C et al. (2005) Alzheimer paired helical filaments (PHFs) studied by high-resolution TEM: what can vertical Pt-C replication tell us about the organization of the pronase-digested PHF core? Microsc Res Tech 67:196-209
Ruben, George C; Wang, Jian-Zhi; Iqbal, Khalid et al. (2005) Paired helical filaments (PHFs) are a family of single filament structures with a common helical turn period: negatively stained PHF imaged by TEM and measured before and after sonication, deglycosylation, and dephosphorylation. Microsc Res Tech 67:175-95
Ruben, G C (1998) Vertical Pt-C replication for TEM, a revolution in imaging non-periodic macromolecules, biological gels and low-density polymer networks. Micron 29:359-96
Ruben, G C; Ciardelli, T L; Grundke-Iqbal, I et al. (1997) Alzheimer disease hyperphosphorylated tau aggregates hydrophobically. Synapse 27:208-29
Ruben, G C; Roos, T B (1997) Conformation of Lac repressor tetramer in solution, bound and unbound to operator DNA. Microsc Res Tech 36:400-16
Ruben, G C (1995) Quantification of particle sizes with metal replication under standard freeze-etching conditions: a gold ball standard for calibrating shadow widths was used to measure freeze-etched globular proteins. Microsc Res Tech 32:312-29
Ruben, G C; Novak, M; Edwards, P C et al. (1995) Alzheimer paired helical filaments, untreated and pronase digested, studied by vertical platinum-carbon replication and high resolution transmission electron microscopy. Brain Res 675:1-12